紫杉醇纳米水化药物在癌症治疗领域的研究进展  

Research Progress of the Paclitaxel Nano-Hydrated Drugs in Cancer Treatment

作　　者：孙圆媛[1] 高静宇 张峰[2] Sun Yuanyuan;Gao Jingyu;Zhang Feng(Beijing Institute for Drug Control （Beijing Center for Health Food and Cosmetics Control）, Beijing, 102206;Agricultural Nanocenter, School of Life Sciences, Inner Mongolia Agricultural University, Hohhot, 010018)

机构地区：[1]北京市药品检验所(北京市保健食品化妆品检验中心),北京102206 [2]农业纳米中心生命科学学院内蒙古农业大学,呼和浩特010018

出　　处：《基因组学与应用生物学》2018年第4期1847-1852,共6页Genomics and Applied Biology

基　　金：国家自然科学基金项目(No.211206054);内蒙古农业大学的纳米生物医药创新团队项目的共同资助

摘　　要：利在众多病症中,癌症是公认的极难治愈的一类疾病,紫杉醇则是有效治疗癌症药物的代表。然而,因为紫杉醇自身的结构使其具有很强的疏水性,限制了药效的发挥。想要提高药效以更有效地治疗癌症,提高紫杉醇的亲水性便是需要克服的首要难题。本综述聚焦于当前已研发出的使紫杉醇发生纳米水化从而具有疏水性的方法,如物理吸附法、简单聚合物包裹法、与其他物质结合形成胶束以及与适宜物质进行逐层自组装等。这些方法都可以制备紫杉醇递送系统,有助于紫杉醇杀伤癌细胞效率的提高,增加癌症的治愈率。Among the many diseases, cancer is recognized as a class of disease that is very difficult to be cured, and paclitaxel is the representative of the effective treatment of cancer drugs. However, paclitaxel has strong hydrophobicity because of its own structure, which limits its efficacy. Improving the hydrophilicity of paclitaxel is the primary problem to overcome in order to improve the efficacy of the drug to treat cancer more effectively. In this paper, we focused on the methods that have been developed to make paclitaxel nano-hydrated and then hydrophobic, such as physisorption-mediated method, simple polymer encapsulation, micelle formation by combining with other substances and layer-by-layer self-assembly with suitable materials. All these methods could be used to prepare paclitaxel delivery system, which chould help to improve the efficiency of paclitaxel killing cancer cells and increase the cure rate of cancer.

关 键 词：紫杉醇 物理吸附 聚合物 胶束 逐层自组装 

分 类 号：R730.5[医药卫生—肿瘤]