脉压指数与颅内外动脉硬化的相关性研究  

Relationship of pulse pressure index with intracranial and extracranial atherosclerosis

作　　者：雷华[1] 江宗泽[1] 杨丽平 李鱼[1] 陈科宇[1] Lei Hua;Jiang Zongze;Yang Liping;Li Yu;Chen Keyu(Department of Neurology , Chongqing Fuling Central Hospital , Chongqing 408000 , Chin)

机构地区：[1]重庆市涪陵中心医院神经内科,408000 [2]重庆市涪陵区人民医院内分泌科

出　　处：《中华老年心脑血管病杂志》2018年第5期522-524,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：重庆市医学科研计划项目(2013-2-184)

摘　　要：目的探讨脉压指数与颅内外动脉硬化的相关性。方法收集我院神经内科住院的脑血管病、周围性眩晕、头痛等患者255例。根据颈部血管彩色多普勒超声及头颈部CT血管成像检查分为正常组99例,斑块组53例,轻度狭窄组53例(狭窄率<30%),中度狭窄组29例(狭窄率30%~69%),重度狭窄组21例(狭窄率70%~99%),根据不同程度狭窄组又分为颅内狭窄组68例及颅外狭窄组35例。记录患者一般情况及血液学指标,完善动态血压,计算平均脉压指数。结果与正常组比较,轻度狭窄组、中度狭窄组和重度狭窄组脉压指数明显升高(0.41±0.08、0.41±0.05 vs 0.38±0.06,P<0.01;0.43±0.05 vs 0.38±0.06,P<0.05)。颅内狭窄组与颅外狭窄组脉压指数比较,差异无统计学意义(0.41±0.06 vs 0.40±0.05,P>0.05)。相关性分析显示,颅内外动脉硬化与脉压指数、高血压、年龄呈正相关(P<0.01),与性别、糖尿病、TC、TG和LDL-C不相关(P>0.05)。结论脉压指数与颅内外动脉硬化具有相关性。Objective To study the relationship of pulse pressure index（PPI）with intracranial and extracranial arteriosclerosis.Methods Two hundred and fifty-five patients with cerebrovascular disease,peripheral vertigo and headache admitted to our hospital were divided into normal control group（n=99）,plaque group（n=53）,mild stenosis group（n=53）with a stenosis rate of30%,moderate stenosis group（n=29）with a stenosis rate of 30%-69%,and severe stenosis group（n=21）with a stenosis rate of 70%-99%according to their head and neck CT vascular imaging.The patients were further divided into intracranial stenosis group（n=68）and extracranial stenosis group（n=35）.Their general condition,laboratory blood test parameters,ambulatory blood pressure（ABP）and mean PPI were recorded.Results The PPI was significantly higher in mild,moderate and severe stenosis groups than in normal control group（0.41±0.08,0.41±0.05 vs0.38±0.06,P〈0.01;0.43±0.05 vs 0.38±0.06,P〈0.05）.However,no significant difference was found in PPI between intracranial and extracranial stenosis groups（0.41±0.06 vs 0.40±0.05,P〉0.05）.Correlation analysis showed that intracranial arteriosclerosis was positively related with PPI,hypertension and age（P〈0.01）,but not related with gender,diabetes,TC,TG and LDL-C（P〉0.05）.Conclusion PPI is related with intracranial arterosclerosis.

关 键 词：颅内动脉硬化 超声检查 多普勒 体层摄影术 X线计算机 

分 类 号：R743[医药卫生—神经病学与精神病学]