老年轻度认知障碍与骨代谢水平的相关性研究  

Correlation between mild cognitive impairment and bone metabolism level in the elderly

作　　者：蒋倩雯[1] 崔佩菁[1] JIANG Qian-wen, CUI Pei-jing(Department of Gerontology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, Chin)

机构地区：[1]上海交通大学医学院附属瑞金医院老年科,上海200025

出　　处：《上海交通大学学报（医学版）》2018年第4期407-410,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金青年基金(81501086);上海市卫生计生系统重要薄弱学科建设项目(2015ZB0503)~~

摘　　要：目的·探讨老年轻度认知障碍(mild cognitive impairment,MCI)与骨代谢水平的相关性。方法·从上海交通大学医学院附属瑞金医院老年科门诊和住院患者中筛选50例老年MCI患者以及90名认知功能正常的老年对照,检测血浆中钙磷代谢调节指标、骨吸收标志物、骨形成标志物的水平,采用简易精神状态量表(mini mental state examination,MMSE)、蒙特利尔认知评估量表(Montreal cognitive assessment,Mo CA)评估认知功能。结果·老年MCI患者血浆骨钙素水平高于对照组(P=0.001),而血钙水平低于对照组(P=0.045)。在MCI患者中,MMSE分值与25-羟维生素D3水平呈正相关(r=0.290,P=0.041),与甲状旁腺激素水平呈负相关(r=-0.349,P=0.025)。结论·老年MCI可能与骨代谢水平相关。Objective · To investigate the correlation between mild cognitive impairment（MCI） and bone metabolism level in the elderly. Methods · Fifty patients with MCI and ninety controls with normal cognitive function were recruited from Department of Gerontology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. Plasma levels of calcium and phosphorus metabolism indicators, bone resorption markers and bone formation markers were measured. Cognitive function was assessed by mini mental state examination（MMSE） and Montreal cognitive assessment（Mo CA）. Results · Plasma level of osteocalcin was elevated in patients with MCI（P=0.001） compared with controls, while plasma level of calcium was decreased in the MCI group（P=0.045）. Among patients with MCI, the score of MMSE positively correlated with plasma level of 25-hydroxy vitamin D_3（r=0.290, P=0.041）, while negatively correlated with plasma level of parathyroid hormone（r=-0.349, P=0.025）. Conclusion · MCI may be correlated with bone metabolism level in the elderly.

关 键 词：轻度认知障碍 骨钙素 血钙 25-羟维生素D3 甲状旁腺激素 

分 类 号：R741.02[医药卫生—神经病学与精神病学]