加巴喷丁联合阿米替林及曲马朵控制神经病理性疼痛的效果及安全性  

Clinical efficacy and safety of gabapentin capsules combined with amitriptyline and tramadol in the treatment of neuropathic pain

作　　者：计忠伟 刘文龙 茹彬 李顺 蔡文君 JI Zhong-wei,LIU Wen-long,RU Bin,et al.(Depantment of Pain Management, the Affiliated Hospital of Hangzhou Medical College,Zhejiang Provincial People＇s Hospital,Hangzhou,Zhejiang 310014, China)

机构地区：[1]杭州医学院附属人民医院浙江省人民医院疼痛科,浙江杭州310014

出　　处：《实用医药杂志》2018年第5期407-410,共4页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨加巴喷丁、阿米替林、曲马朵三种药物联合治疗神经病理性疼痛(neuropathic pain,NPP)的疗效及安全性。方法选取2016年9月—2017年7月在笔者所在科治疗的NPP患者共100例,对照组47例,试验组53例。对照组单用加巴喷丁胶囊口服治疗,试验组给予加巴喷丁胶囊同时联合阿米替林片、曲马朵缓释片口服治疗,分别于用药前、用药后第1周、第4周对患者疼痛程度进行VAS评分,同时在第4周对患者出现的药物不良反应进行评估。结果相比于治疗前,在用药第1周和第4周两组VAS评分均有下降(P<0.05),试验组VAS评分下降更为明显(P<0.05)。试验组的不良反应发生率低于对照组(P<0.05)。对于同一患者三种药物联合用药较单用加巴喷丁胶囊VAS评分下降(P<0.05),且不增加药物不良反应(P>0.05)。结论加巴喷丁、阿米替林、曲马朵三种药物联合能有效控制神经病理性疼痛,减轻药物不良反应。Objective To investigate the clinical efficacy and safety of gabapentin capsules（GBP）combined with amitriptyline and tramadol in the treatment of patients with neuropathic pain（NPP）. Methods Totally 100 NPP patients at different degree were selected and divided into observation group（n =47） and experimental group（n=53） by medical record number. Observation group was given GBP only,while trial group was given GBP,amitriptyline and tramadol. The pain-relieving intensity（by VAS） of the patients was determined before the medication（T0）,in the first week（T1） and the fourth week（T2） after the medication. The adverse drug reactions were evaluated at the fourth week. Results The VAS scores in the two groups on T1 and T2 were statistically significant lower than the corresponding results on T0（P〈0.05）. However,there were statistically significant differences between the two groups（P〈0.05）. The total adverse reaction rate of experimental group was significantly lower than that of observation group（P〈0.05）. For the same patient,the VAS scores of drug combinations was statistically significant lower than single drug（P〈0.05）,and there was no significantly difference in the adverse reaction rate（P〉0.05）. Conclusion GBP combined with amitriptyline and tramadol in the treatment of NPP can effectively control the pain of the patients,significantly reduce the scores of VAS and lower the rate of adverse drug reactions.

关 键 词：加巴喷丁 阿米替林 曲马朵 神经病理性疼痛 

分 类 号：R747[医药卫生—神经病学与精神病学]