石家庄市区省直幼儿园单纯性肥胖儿童全血氨基酸水平调查分析  

Research of amino acids in the whole blood of children with simple obesity in provincial kindergarten in Shijiazhuang

作　　者：马书军[1] 闫承生[1] 赵庆伟[1] 裴菊英[1] 王立宁[1] 刘云[1] 赵志娜 MA Shu Jun;YAN Cheng Sheng;ZHAO Qing Wei;PEI Ju Ying;WANG Li Ning;LIU Yun;ZHAO Zhi Na(Hebei Provincial Maternity and Child Health Center, Hebei 050031, China)

机构地区：[1]河北省妇幼保健中心,石家庄050031

出　　处：《中国妇幼卫生杂志》2018年第1期10-13,共4页Chinese Journal of Women and Children Health

基　　金：中国疾病预防控制中心妇幼保健中心合生元母婴营养与健康研究基金资助(2016FYH018)

摘　　要：目的研究石家庄市区省直幼儿园儿童单纯性肥胖发生率及单纯性肥胖儿童全血11种氨基酸水平,探讨全血氨基酸水平与儿童肥胖的关系,为临床诊断和治疗干预提供科学依据。方法对省直幼儿园全体3~6岁3516例儿童进行体检,随机选出54名单纯性肥胖儿童做为观察组,按照一比一配对原则选出54名正常体重儿童作为对照组,采用串联质谱法对以上儿童进行全血氨基酸测定,利用SPSS11.0统计软件包进行数据处理。结果观察组患儿的全血氨基酸水平与对照组存在差异,其中丙氨酸(ALa)、缬氨酸(Val)、鸟氨酸(Orn)、亮氨酸(Leu)、蛋氨酸(Met)、苯丙氨酸(Phe)和酪氨酸(Tyr)高于对照组,差异有统计学意义(P<0.05);甘氨酸(Gly)、精氨酸(A rg)、瓜氨酸(Cit)、脯氨酸(Pro),两组间差异无统计学意义(P>0.05)。结论单纯性肥胖儿童多数全血氨基酸水平高于正常体重儿童,动态监测血氨基酸水平,可以为临床医生对单纯性肥胖儿童进行干预提供科学依据。Objective To explore the relationship between the levels of amino acids in whole blood and children obesity by the incidence of simple obesity among children in provincial kindergarten in Shijiazhuang and provide the scientific evidence for clinical diagnosis and treatment of children with simple obesity. Method A total 54 children with simple obesity（observation group） were randomly selected from 3516 3-6 years old children who participated the physical examination in provincial kindergarten. According to the 1： 1 matching principle,54 children with normal weight were also selected as the control group. All of the children were tested the levels of amino acids in whole blood by tandem mass spectrometry（MS/MS）. SPSS 11. 0 statistical software package was used to analyze the data. Result There was difference in the level of the whole blood amino acid between the two groups. The levels of ALa,Val,Orn,Leu,Met,Phe and Tyr were higher of observation group than those of the control group. The difference was statistically significant（P〈0. 05）. There was no statistical difference（P〈0. 05） in the levels of Gly,Arg,Cit and Pro between the two groups.Conclusion The whole blood amino acid levels of children with simple obesity was higher than the normal weight children. To dynamic monitor the whole blood amino acid levels can provide a scientific evidence for doctors to prevent the simple obesity among children.

关 键 词：儿童 单纯性肥胖 串联质谱 氨基酸 

分 类 号：R723.14[医药卫生—儿科]