^18F-FDG符合线路SPECT／CT在尘肺病大阴影良恶性鉴别中的应用价值  

Clinical Value of ^18F-FDG SPECT/CT in Differentiation between Benign Lesions and Lung Cancer for Large Shadows in Patients with Pneumoconiosis

作　　者：李亚威[1] Li Yawei(Department of Medical Imaging, Beijing Hospital, Capital Medial University, Beijing 101149, P.R. China)

机构地区：[1]首都医科大学附属北京胸科医院医学影像学科,101149

出　　处：《结核病与胸部肿瘤》2018年第1期64-68,共5页Tuberculosis and Thoracic Tumor

摘　　要：目的探讨^18F-FDGSPECT／CT对尘肺病大阴影良恶性鉴别的临床应用价值。方法回顾分析50例尘肺病Ⅲ期患者肺内的94个大阴影病灶，行^18F-FDGSPECT／CT检查，并计算大阴影的最大标准摄取值（SUVmax）；通过卡方检验探讨大阴影^18F-FDG摄取高低、分布特点与肺癌之间的相关性。结果50例患者单纯尘肺病大阴影直径范围为（4．35±1．17）cm，SUVmax范围为4．82±1．77；肺癌病灶直径范围为（4．98±0．67）cm，SUVmax范围为6．82±1．06。尘肺结节病灶和肺癌病灶的直径及SUVmax的差异均无统计学意义（P〉0．05）。尘肺病大阴影呈对称分布者比孤立性分布者良性可能性更大，且差异有统计学意义（P〈0．05）；尘肺病大阴影孤立性分布且SUVmax摄取高者较对称性分布者或病灶孤立性分布且SUVmax摄取低者肺癌的可能性更大，且差异有统计学意义（P〈0．05）。结论尘肺病大阴影^18F—FDG摄取低或者^18F-FDG摄取高且呈对称分布时，多提示良性尘肺结节可能。尘肺病大阴影孤立性分布且^18F-FDG摄取高者较大阴影对称性分布者或病灶孤立性分布且SUVmax摄取低者肺癌的可能性更大。Objective To evaluate the clinical value of ^18F-FDG SPECT/CT in the differentiation between benign lesions and lung cancer for large shadows in patients with pneumoconiosis. Methods A retrospective study was conducted in 50 patients with a confirmed diagnosis of pneumoconiosis who had a total of 94 large shadows in the lung fields as shown by ^18F-FDG SPECT/CT imaging, and ^18F-FDG SPECT/CT uptake was evaluated using the maximum standardized uptake value（SUVmax）.The differences between the distribution characteristics ofpneumoconiosis nodules with high 18F-FDG uptake and the possibility ofhmg cancer were evaluated by chi-square test. Results Among fifty patients, the diameter range ofpneumoconiosis nodules with high ^18F-FDG uptake was（4.35 ± 1.17）cm, and the SUV max range was 4.82 ± 1.77 ; the diameter range of lung cancer with high 18F-FDG uptake was （4.98 ±0.67） cm, and the SUVmax range was 6.82 ± 1.06.There were no significant diferences in diameter and SUVmax between the lung cancer and pneumoconiosis nodules with high ^18F-FDG uptake （P 〉0.05 for both）. Symmetrical lesions for large shadows in patients with pneumoconiosis were more likely to be considered as benign pneumoconiosis nodules than isolated lesions, and the difference was statistically significant （P 〈0.05）.Isolated lesions with high ^18F-FDG uptake for large shadows in patients with pneumoconiosis were more likely to be considered as lung cancer than symmetrical lesions for large shadows in patients with pneumoconiosis or the isolated lesions without 18F-FDG uptake, and the diference was statistically significant（P 〈0.05）. Conclusion In ^18F-FDGSPECT/CT imaging for patients with pneumoconiosis, the lung lesions without ^18F-FDG uptake or symmetrical lesions with high 18F-FDG uptake are considered as benign pneumoconiosis nodules.However.isolated lesions with high 18F-FDG uptake for large shadows in patients with pneumoconiosis are more likely to be considered as lung cancer than symmetrical lesions for large sh

关 键 词：尘肺 大阴影 肺癌 体层摄影术 x线计算机 

分 类 号：R734.2[医药卫生—肿瘤]