益气活血通脉汤对糖尿病动脉硬化闭塞症患者炎症细胞因子及内皮功能的影响  

Effect of Yiqi Huoxue Tongmai Decoction on Inflammatory Cytokines and Endothelial Function in Diabetic Patients with Atherosclerosis Occlusion

作　　者：李亚南[1] 刘小勇 宋兆华 LI Ya-nan;LIU Xiao-yong;SONG Zhao-hua(Henan Province Hospital of Traditional Chinese Medicine （TCM） , Zhengzhou 450002, China;Luoyang No. 1 Hospital of TCM, Luoyang 471099, China;Luohe Medical College, Luohe 462002, China)

机构地区：[1]河南省中医院,郑州450002 [2]洛阳市第一中医院,河南洛阳471099 [3]漯河市医学高等专科学校,河南漯河462002

出　　处：《中国实验方剂学杂志》2018年第10期193-199,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省基础与前沿技术研究计划项目(142300410239)

摘　　要：目的：观察益气活血通脉汤对糖尿病动脉硬化闭塞症（ASO）患者炎症细胞因子及内皮功能的影响。方法：按随机数字将2016年4月至2017年8月在河南省中医院治疗的104例ASO患者分为两组,各52例,对照组采用常规方法治疗（包括抗凝、抗血小板聚集、降血压、降血糖、有氧运动锻炼、高压氧呼吸、保健按摩等方法）,在对照组的基础上,观察组采用益气活血通脉汤治疗,治疗后,观察两组的疗效,并观察两组治疗前后的踝/肱指数（ABI）,血流动力学指标,炎症因子,内皮功能。结果：（1）疗效,治疗后,观察组的总有效率为96.15%,对照组的总有效率为84.62%,观察组优于对照组（χ~2=3.983,P〈0.05）;（2）ABI,观察组治疗后的ABI均明显高于对照组（P〈0.05）;（3）血流动力学,治疗后,观察组治疗后的全血黏度（ηb）,血浆黏度（ηp）,红细胞电泳（EEP）,血沉（ESR）,纤维蛋白原（Fib）均明显低于对照组（P〈0.05,P〈0.01）;（4）炎症细胞因子,治疗后,观察组治疗后的白细胞介素（IL）-1,IL-6,肿瘤坏死因子（TNF）-α,高敏C反应蛋白（hs-CRP）均明显低于对照组（P〈0.05,P〈0.01）;（5）内皮功能,治疗后,观察组治疗后的内皮脂酶（EL）,内皮素-1（ET-1）,单核细胞趋化蛋白-1（MCP-1）均明显低于对照组（P〈0.01）,一氧化氮（NO）明显高于对照组（P〈0.01）。结论：益气活血通脉汤治疗动脉硬化闭塞症的疗效较好,能够改善血液高凝状态,稳定血流动力学,抑制炎症反应,改善血管内皮细胞的功能。Objective：To observe the effect of Yiqi Huoxue Tongmai decoction on inflammatory cytokines and endothelial function in diabetic patients with atherosclerosis occlusion.Method：According to the random number method,104 cases of atherosclerosis occlusion treated in our hospital from April 2016 to August 2017 were divided into two groups.The control group（52 cases） was treated with conventional methods（including anticoagulation,anti-platelet aggregation,blood pressure lowering,blood glucose lowering,aerobic exercise,hyperbaric respiration,health massage）.In addition to the therapy of the control group,the observation group（52 cases） was also treated with Yiqi Huoxue Tongmai decoction.After treatment,the efficacy of two groups was observed,and ankle/brachial index（ABI）,hemodynamic index,inflammatory factor and endothelial function of the two groups were observed.Result：Efficacy,after treatment,the total effective rate of the observation group was 96.15%,while the total effective rate of the control group was 84.62%,with statistically significant differences（χ~2= 3.983,P〈0.05）.ABI,after treatment,ABI in observation group was significantly greater than that in control group（P〈0.05）.Hemodynamics：after treatment,hemodynamics,ηb,ηp,erythrocyte electrophoresis（EEP）,erythrocyte sedimentation rate（ESR） and Fib of the observation group were significantly lower than those of the control group（P〈0.05,P〈0.01）.Inflammatory cytokines,after treatment,interleukin（IL）-1,IL-6,tumor necrosis factor（TNF）-α and hypersensitive C-reactive protein（hs-CRP） of the observation group were significantly lower than those of the control group（P〈0.05,P〈0.01）.Endothelial function,after treatment,endothelial lipase（EL）,endothlin-1（ET-1） and monocyte chemo attractant protein-1（MCP-1） of the observation group were significantly lower than those in control group（P〈0.01）,and nitricoxide（NO） was significantly higher than that of control group（P〈0.01）.Con

关 键 词：益气活血通脉汤 动脉硬化闭塞症 炎症细胞因子 内皮功能 

分 类 号：R22[医药卫生—中医基础理论] R24[医药卫生—中医学]