直肠癌患者肿瘤抑制因子SEMA3F、CYLD与miR-454表达水平及其相关性  

Expression of tumor suppressor factors SEMA3F, CYLD and miR-454 in rectal cancer patients

作　　者：王勇[1] 宋林繁 杨光[1] 沈海峰[1] 范亚召 WANG Yong;SONG Lin-fan;YANG Guang;SHEN Hai-feng;FAN Ya-zhao(Department of Anorectal Surgery, The Fourth People＇s Hospital of Hengshui City（Hebei 053000, China)

机构地区：[1]河北省衡水市第四人民医院肛肠外科,河北衡水053000

出　　处：《中国现代普通外科进展》2018年第2期106-109,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:研究肿瘤抑制因子SEMA3F、CYLD及miR-454在直肠癌患者中的表达水平。方法:2016年1~3月,21例直肠癌患者分别检测癌灶组织、癌病灶周围组织以及直肠正常组织中的肿瘤抑制因子SEMA3F、CYLD及miR-454表达水平,分析肿瘤抑制因子SEMA3F、CYLD与miR-454的相关性,探讨三者在直肠癌发生、发展中的作用。结果:癌组织、癌旁组织以及正常组织中的SEMA3F、CYLD与miR-454表达差异均具有统计学意义(P<0.01)。转移组患者癌组织中SEMA3F、CYLD均显著低于无转移组,miR-454显著高于无转移组(P<0.01)。高分化组CRC组织中SEMA3F、CYLD表达水平显著高于中低分化组,miR-454表达显著低于中低分化组(P<0.01)。肿瘤抑制因子CYLD与miR-454具有显著负相关性(r=-0.971,P<0.01)。肿瘤抑制因子SEMA3F与miR-454具有显著负相关性(r=-0.955,P<0.01)。结论:肿瘤抑制因子SEMA3F、CYLD在直肠癌早期可见高表达,随着病情进展表达水平逐渐下降;而miR-454则起到促进直肠癌细胞异常增殖及转移的作用,随着疾病进展表达水平逐渐升高,且与SEMA3F、CYLD均呈显著负相关;肿瘤抑制因子SEMA3F、CYLD及miR-454表达对于直肠癌的诊断及病情进展、预后的评估均具有重要的参考价值。Objective： To study the expression of tumor suppressor factors SEMA3F, CYLD and miR-454 in rectal cancer. Methods： 21 patients with colorectal cancer admitted in our hospital from January to March in 2016 were selected as the study materials. The tumor inhibitory factor SE-MA3F in rectal cancer tissue, cancerous surrounding tissue and normal rectum tissue were detected respectively, CYLD and miR-454, and to analyze the correlation between tumor suppressor factors SEMA3F, CYLD and miR-454, and to explore their roles in the carcinogenesis and progression of rectal cancer. Results： The expression of SEMA3F, CYLD and miR-454 in cancer tissue, para- cancer tissue and normal tissue were statistically significant （P〈0.01）. The levels of SEMA3F and CYLD were significantly lower in patients with metastasis than those without metastasis, and miR-454 was significantly higher than that in patients without metastasis （P〈0.01）. The expression level of SEMA3F and CYLD in CRC tissues was significantly higher than that in moderately and poor- ly differentiated tissues, and the expression of miR-454 was significantly lower than that in moder- ately and poorly differentiated ones （P〈0.01）. There was significant negative correlation between tu- mor suppressor CYLD and miR-454 （r=-0.971, P〈0.01）. There was a significant negative correlation between tumor inhibitory factor SEMA3F and miR-454（r=-0.955, P〈0.01）. Conclusion： The tumor suppressor factors SEMA3F and CYLD play an important role in inhibiting the formation and prolifer- ation of cancer cells in colorectal cancer. The expression of tumor suppressor factors SEMA3F and CYLD in colorectal cancer is high in the early stage and gradually declines with the progression of the disease. MiR-454 can promote the growth of rectal cancer cells The expression of tumor suppressor factors SEMA3F, CYLD and miR-454 in colorectal carcinoma were significantly higher than those in SEMA3F and CYLD. The expression of tumor suppressor factors such as SEMA3F, CYL

关 键 词：直肠癌 SEMA3F CYLD miR-454 

分 类 号：R735.37[医药卫生—肿瘤]