42例眼睑鳞状细胞癌临床组织病理学特点及预后相关因素分析  

Clinical and histopathologic features of eyelid squamous cell carcinoma and its prognostic predictors

作　　者：金书红[1] 王一鹏[1] 张红鸽[2] 陈拥军[1] JIN Shu-hong1 , WANG Yi-peng1, ZHANG Hong-ge2, CHEN Yong-jun1(1. Anyang Ophthalmology Hospital, Henan 455000, China; 2. Department of Pathology, Anyang People＇s Hospital, Henan 455000, Chin)

机构地区：[1]河南省安阳市眼科医院,455000 [2]河南省安阳市人民医院病理科,455000

出　　处：《眼科》2018年第2期99-102,共4页Ophthalmology in China

摘　　要：目的分析眼睑鳞状细胞癌的临床及组织病理学特点,探讨影响眼睑鳞状细胞癌的临床预后因素。设计回顾性病例系列。研究对象安阳市眼科医院2000年1月至2011年3月42例(42眼)眼睑鳞状细胞癌患者。方法依据原始记录和随访情况,对临床及组织病理学因素进行统计分析。采用COX回归分析复发相关因素,生存分析采用Kaplan-Meier法。术后随访(45.7±9.87)个月。主要指标患者年龄、性别、病程、肿瘤解剖部位、肿瘤T分类、肿瘤病理学分级及治疗方法。结果42例眼睑鳞状细胞癌患者平均年龄(61.9±7.82)岁;其中男24例(57.1%);发病部位以下睑为多(18/42);肿瘤T分类4例T1,7例T2,17例T3,14例T4。病程长、肿瘤T分类级别高是肿瘤复发的危险因素;肿瘤T分类与眼睑鳞状细胞癌患者的5年生存率呈相关性,T分类级别越高,肿瘤相关死亡率越高(r=8.818,P=0.035)。结论眼睑鳞状细胞癌病程越长、肿瘤T分类级别越高时,肿瘤的复发率增高;肿瘤T分类级别越高时,肿瘤相关死亡率越高。Objective To analyze the clinical and histopathologic features and the factors associated with prognosis of the eyelid squamous cell carcinoma. Design Retrospective case series. Participants Forty-two cases of eyelid squamous cell carcinoma during January 2000 and March 2011 in Anyang Ophthalmology Hospital. Methods According to the initial records and follow-up feedback,the clinical and histopathologic features were analyzed. The related factor of recurrence was analyzed by COX regression,and survival analysis using kaplan-meier method. The postoperative patients were followed-up for（ 45. 7 ± 9. 87） months.Main Outcome Measures Age,gender,disease course,disease region,T classification,pathological grade,treatment methods. Results The age of 42 cases varied from 36 to 81 years old,and the mean age was 61. 9 ± 7. 82 years old. There were 24（ 57. 1%） males and 18（ 42. 9%） females. The tumors mainly located at the lower eyelid. The sample included four T1,seven T2,seventeen T3,and fourteen T4 cases.The statistics analysis showed the length of the disease duration and the T classification were significantly associated with local recurrence（ P 0. 05）. The disease duration and the T classification were two risk factors for tumor recurrence. And the T classification was correlated with the five-year survival rate,the higher grade of T classification,the higher tumor-related mortality（ r = 8. 818,P = 0. 035）. Conclusion The clinical outcome of the eyelid squamous cell carcinoma is related with the length of the disease duration and the T classification of the tumor. The longer disease duration or the higher T classification,predicted a higher recurrence rate of tumor. And the mortality rate increased with the higher T classification.

关 键 词：鳞状细胞癌 眼睑 组织病理学 TNM分期 

分 类 号：R739.71[医药卫生—肿瘤]