替吉奥同步高-低氧放疗治疗局部晚期胰腺癌的临床观察  

Clinical study of S-1 chemotherapy plus high-low oxygen radiotherapy synchronously in treatment of locally advanced pancreatic cancer

作　　者：孙衍伟 丁兆军 周玉美 安永恒[2] Sun Yanwei;Ding Zhaojun;Zhou Yumei;An Yongheng(Department of Oncology, Rizhao People＇s Hospital, Jining Medical College, Rizhao 276826, Chin;Cancer Center, the Affiliated Hospital of Qingdao University, Qingdao 266003, China)

机构地区：[1]济宁医学院附属日照市人民医院肿瘤科,276826 [2]青岛大学附属医院肿瘤治疗中心,266003

出　　处：《肿瘤研究与临床》2018年第4期258-261,共4页Cancer Research and Clinic

基　　金：青岛市科技发展指导计划（2000-2-36）

摘　　要：目的 观察替吉奥同步高-低氧放疗治疗局部晚期胰腺癌的临床效果及不良反应.方法 将2013年1月至2015年10月日照市人民医院和青岛大学附属肿瘤医院64例局部晚期胰腺癌患者按信封法随机分为研究组和对照组,每组32例.研究组采用口服替吉奥化疗同步高-低氧放疗,对照组采用吉西他滨静脉滴注化疗,比较两组的有效率、疾病控制率、临床获益率、远处转移率、生存率及不良反应.结果 研究组与对照组有效率比较[70.4 %（19/27）比32.1 %（9/28）],差异有统计学意义（χ^2=8.04,P〈0.01）;两组疾病控制率、临床获益率、远处转移率比较[88.9 %（24/27）比67.9 % （19/28）;77.8 %（21/27）比57.1 %（16/28）;63.0 %（17/27）比71.4 %（20/28）],差异均无统计学意义（χ^2值分别为3.56、2.66、0.45,均P〉0.05）;两组1、2年生存率比较[63.0 %（17/27）比32.1 %（9/28）;37.0 %（10/27）比10.7 %（3/28）],差异均有统计学意义（χ^2值分别为5.24、5.28,均P〈0.05）.两组患者严重不良反应发生情况差异无统计学意义（P〉0.05）.结论 替吉奥同步高-低氧放疗治疗局部晚期胰腺癌患者的有效率及1、2年生存率优于吉西他滨静脉化疗,不良反应无增加.Objective To evaluate the clinical efficacy and adverse reactions of S-1 chemotherapy plus high-low oxygen radiotherapy synchronously in treatment of patients with locally advanced pancreatic cancer. Methods Sixty-four patients with locally advanced pancreatic cancer in Rizhao People＇s Hospital and the Affiliated Hospital of Qingdao University from January 2013 to October 2015 were randomly divided into study group and control group by using envelope method, in which the study group was treated with oral administration of S-1 plus high-low oxygen radiation synchronously and the control group with intravenous gemcitabine chemotherapy. The efficiency, disease control rate, clinical benefit rate, distant metastasis rate, survival rate and adverse reactions of the two groups were compared. Results The effective rates of the study group and the control group were 70.4 %（19/27）and 32.1 %（9/28）,the difference was statistically significant （χ^2=8.04,P〈0.01）, and the disease control rates were 88.9 % （24/27） and 67.9 % （19/28） （χ^2= 3.56, P 〉0.05）. The clinical benefit rates of the study group and the control group were 77.8 % （21/27） and 57.1 % （16/28） （χ^2=2.66,P 〉0.05）, and the distant metastasis rates were 63.0 %（17/27） and 71.4 %（20/28） （χ^2=0.45, P 〉 0.05）. The 1-year survival rates of the study group and the control group were 63.0 % （17/27） and 32.1 % （9/28）, and the 2-year survival rates were 37.0 % （10/27） and 10.7 % （3/28）, the differences were statistically significant （χ^2= 5.24, P 〈 0.05; χ^2= 5.28, P〈 0.05）. While there were no significant difference in the incidence of serious adverse reactions between the two groups （P〉 0.05）. Conclusion The treatment of locally advanced pancreatic cancer with S-1 plus high-low oxygen radiotherapy synchronously is better than that with intravenous gemcitabine chemotherapy in terms of effective rate, 1-year survival rate and 2-year survival rate,with no increase of adverse reactio

关 键 词：胰腺肿瘤 放射疗法 计算机辅助 替吉奥 吉西他滨 

分 类 号：R735.9[医药卫生—肿瘤]