PI3K/Akt/mTOR通路在炎症相关疾病中分子机制研究进展  

Progress in molecular mechanism of PI3K/Akt/mTOR pathway in inflammation related diseases

作　　者：嵇莹莹 龚国清[1] JI Yingjing;GONG Guoqing(School of Pharmacy, China Pharmaceutical University,Nanjing 211198, China)

机构地区：[1]中国药科大学药学院,江苏南京211198

出　　处：《药学研究》2018年第4期226-229,共4页Journal of Pharmaceutical Research

基　　金：国家"重大新药创制"科技重大专项资助项目(No.6100010053A)

摘　　要：炎症是一种机体应对感染、组织损伤或者细胞应激的反应,并且可以通过修复机制恢复组织功能。炎症发生时会引起多条信号通路的激活,包括核转录因子-κB(NF-κB)通路、Janus激酶/信号转导与转录激活子(JAK/STAT)通路、丝裂原活化蛋白激酶(MAPK)通路以及磷脂酰肌醇-3-激酶/蛋白激酶B/雷帕霉素靶蛋白(PI3K/Akt/mTOR)通路等。本文综述了近年来磷脂酰肌醇-3-激酶/蛋白激酶B/雷帕霉素靶蛋白通路在炎症相关疾病中的分子作用机制,为研发以磷脂酰肌醇-3-激酶/蛋白激酶B/雷帕霉素靶蛋白为靶点的药物提供理论依据。Inflammation is a response that an organism use it to resolve infection,tissue injury or other cellular stress,and to restore tissue function through repair mechanisms. Multiple signaling pathways are activated during the onset of inflammation,including the NF-kappa B pathway,the JAK/STAT pathway,the MAPK pathway,and the PI3 K/Akt/mTOR pathway.This review summarized the molecular mechanism of PI3 K/Akt/mTOR pathway in inflammatory related diseases in recent years,and provided a theoretical basis for developing PI3 K/Akt/mTOR targeted drugs.

关 键 词：炎症 信号通路 磷脂酰肌醇-3-激酶/蛋白激酶B/雷帕霉素靶蛋白通路 

分 类 号：R363[医药卫生—病理学]