锈毛草莓积雪草合剂对STZ小鼠降血糖作用研究  

Antidiabetic effects of Fragaria nilgerrensis and Centella asiatica compound on STZ-induced diabetic mice

作　　者：高良才[1] 王欣怡 陆诗韵 周梦璇 陈清 林青楠 GAO Liangcai;WANG Xinyi;LU Shiyun;ZHOU Mengxuan;CHEN Qin;LIN Qingnan(Department of Biology Science, East China Normal University, Shanghai 200241, China)

机构地区：[1]华东师范大学生命科学学院,上海200241

出　　处：《广西植物》2018年第4期451-456,共6页Guihaia

基　　金：上海市科委科研基金(16DZ2348900);国家大学生创新项目(201610269091)~~

摘　　要：采用75%乙醇萃取锈毛草莓及积雪草,制备成合剂,通过STZ诱导建立糖尿病小鼠模型,随机分为模型组、低剂量组及高剂量组,分别以蒸馏水、4及8 g·kg^(-1)锈毛草莓积雪草合剂灌胃,1次·d^(-1),持续4周,另设正常组作为对照。探究绣毛草莓积雪草合剂对糖尿病小鼠的降血糖效果及作用机制。结果表明:(1)不同剂量的锈毛草莓积雪草合剂均能显著降低糖尿小鼠血糖值,提高糖耐量并减轻其多食、多饮、多尿的症状。(2)低剂量组小鼠血清TC、TG含量较模型组有显著提高(P<0.01或P<0.05),肝脏SOD、CAT活性显著提高(P<0.05),MDA含量明显降低。(3)低剂量黄毛草莓积雪草合剂效果优于二甲双胍,毒性实验显示锈毛草莓积雪草合剂实属无毒。该研究结果表明锈毛草莓积雪草合剂具有降血糖作用,同时能够降低糖尿病小鼠的血脂水平,其作用机制可能与提高肝脏抗氧化能力有关。We extracted medicine compound（FN-MC）by 75%ethanol.STZ-induced diabetic mice were randomly divided into model,low-dose and high-dose groups,respectively,and treated with distilled water and FN-MC at doses of 4and 8 g·kg^（-1）for 4 weeks.Control group was treated with distilled water.The results showed that FN-MC could significantly lower the fasting blood glucose,reduced food and water intake,and improved the level of OGGT.Low-dose FN-MC could obviously increase the levels of TC and TG（P〈0.01 or P〈0.05）,decrease the level of MDA,enhance the activities of SOD and CAT（P〈0.05）.Besides,Low-dose FN-MC was more effective than metformin.Toxicity test showed that FN-MC was non-toxic.In conclusion,FN-MC could decrease blood glucose in STZ-induced diabetic mice by mechanisms of enhancing the activity of antioxidant in liver.

关 键 词：锈毛草莓 STZ 糖尿病 降血糖 抗氧化 

分 类 号：Q946.3[生物学—植物学]