恩度联合紫杉醇不同给药时序对肺癌荷瘤小鼠的抗肿瘤效应观察  

Observation Of The Antitumor Effect Of Endostar Combined With Taxel Under Different Administration Sequences

作　　者：吴芳[1] 陈凤舞 刘方文 纪巧 王小慧 郭妮 WU Fang;CHEN Fengwu;LIU Fangwen(The First Affiliated Hospital of Nanchang University,Nanchang,33000)

机构地区：[1]南昌大学第一附属医院,330006 [2]宜春市人民医院,336000 [3]赣州市上犹县人民医院,341200

出　　处：《实用癌症杂志》2018年第5期697-699,共3页The Practical Journal of Cancer

基　　金：江西省卫生厅科技计划(20133022)

摘　　要：目的恩度与紫杉醇不同给药时序的抗肿瘤效应。方法将荷瘤裸鼠分为同时给药组,先恩度给药组,模型组,空白组。绘制移植瘤生长曲线,计算抑瘤率。检测裸鼠血中aCECs数量,分析不同给药时序抗肿瘤的效应,包括肿瘤大小变化,aCECs数量变化。结果同时给药组[(36.32±30.58)mm^3]与先恩度给药组[(112.46±71.78)mm^3]的对肿瘤生长的抑制均优于模型组[(214.84±93.57)mm^3](P=0.002,P=0.010)。同时给药组对肿瘤生长的抑制明显优于先恩度组(P=0.020);两个用药组的aCECS数量均明显低于模型组,同时用药组低于先恩度给药组(P<0.076)。结论同时用药组的抑瘤效果好于先恩度组。CECs可能可以预测化疗疗效。Objective To observe the antitumor effect of endostar combined with taxel under different administration sequences. Methods Nude mice with transplantable tumor were randomly divided into 4 groups,Concurrent administration group,Endo-first group,Model group and blank control group. The volume of transplantable tumor were measured. The test of circulating endothelial cells（ CECs） were accomplished. Results The transplantable tumor growth inhibition of concurrent administration group（36. 32 ± 30. 58 mm^3）was better than that of the endo-first group（112. 46 ± 71. 78 mm^3） during treatment,neither of them were worse than that of the model group（214. 84 ± 93. 57 mm^3,P = 0. 002,P = 0. 010）. The amount of CECs in the the concurrent administration was lower than that of endo-first group group,those groups of aCECS were significantly lower than those of the model group. Conclusion In comparison with the endo—first group. the anti-tumor effect of the concurrent administration group are better. CECs may predict the efficacy of chemotherapy.

关 键 词：A549 恩度 紫杉醇 给药时序 aCECs 

分 类 号：R734.2[医药卫生—肿瘤]