转铁蛋白受体在肿瘤研究中的进展  

Progress of Transferrin Receptor in Tumor Research

作　　者：韩冬梅 赵一帆 李江林[1] 叶茂[1] HAN Dong-mei, ZHAO Yi-fan, LI Jiang-lin, YE Mao(College of Biology, Hunan University, Changsha 410082, Chin)

机构地区：[1]湖南大学生物学院,湖南长沙410082

出　　处：《福建师范大学学报（自然科学版）》2018年第3期110-116,共7页Journal of Fujian Normal University：Natural Science Edition

基　　金：国家重点基础研究发展计划(973计划)资助项目(2013CB932702);国家自然科学基金资助项目(81272220;81402304;81672760);湖南省自然科学基金资助项目(2016JJ3048)

摘　　要：综述了转铁蛋白受体的结构及功能,其介导铁离子的途径有两种:循环机制,溶酶体降解机制.转铁蛋白受体在肿瘤细胞和其相对应正常细胞,表达水平升高,被认为是一种有效的肿瘤标志物.总结了以转铁蛋白受体为肿瘤靶向性治疗的研究进展.最后讨论了以转铁蛋白受体为靶点的治疗,目前存在的问题及展望.This review mainly talked about the structure of transferrin receptor and its biological function as the primary pathway for cellular iron transport. Two transport mechanisms are found：recycling pathway and degradation pathway. The development of tranferrin recepter as tumour biomaker for tumour therapy was also sunmmarized. Finally,problems and prospects of tranferrin recepter as a therapeutic traget were discussed.

关 键 词：转铁蛋白受体 肿瘤 靶向治疗 

分 类 号：R730.5[医药卫生—肿瘤]