炎性衰老发生原因的研究进展  

The reasons for inflamm-aging

作　　者：杜红梅[1,2] 王亚君[1] 朱喜科[1] Du Hongmei, Wang Yajun, Zhu Xike(Research Center, Shengjing Hospital China Medical University,Shenyang 110000, China ;2 Department of Ontology, Shengjing Hospital of China Medical University, Shenyang 110000, China)

机构地区：[1]中国医科大学附属盛京医院实验研究中心,沈阳110000 [2]中国医科大学附属盛京医院肿瘤内科,沈阳110000

出　　处：《国际免疫学杂志》2018年第2期222-226,共5页International Journal of Immunology

摘　　要：炎性衰老是自然衰老进程中一种低度、慢性炎症状态，这种状态与严重的老年病发生发展相关。老年病有共同的炎症机制，因此对抗衰老时，最好的策略可能是在不减弱炎症反应的基础上减轻炎性衰老。为了达到这个目的，需要揭示炎性衰老发生的复杂机制，以便给予定向干预，提高老年人群的健康状态。The term ＇inflamm-ageing’ indicates the low-grade chronic inflammatory status characteristic of the ageing process.Such state is associated with the frailty, development, and progression of severe, age-related conditions.This phenomenon has become more evident with the recent dramatic increase in life expectancy, as the human immune system has to face antigen exposure several decades more than in past.These age-related diseases share a common inflammatory pathogenesis.In this framework, one of the most fascinating anti-ageing strategies seems to be able to decrease inflammageing without compromising the physiological role of inflammation, which is fundamental for survival.To this end, it is urgent to clarify the complex mechanisms underpinning inflammageing in order to carry out targeted therapeutic interventions towards an improvement of the health status in the elderly population.

关 键 词：衰老 炎症 免疫细胞 线粒体 表观遗传学 

分 类 号：R363[医药卫生—病理学]