基于格兰杰因果关系磁刺激穴位对亚健康失眠的脑功能网络分析  

Brain functional network analysis of magnetic stimulation at acupoints for sub-health insomnia based on Granger causality

作　　者：郑威 于洪丽[1] 丁卫国 吴霞 徐桂芝[1] 郭磊[1] 陈静[2] 魏丽[2] ZHENG Wei1, YU Hongli1, DING Weiguo2, WU Xia1, XU Guizhi1, GUO Lei1, CHEN Jing2, WEI Li2(1. State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130 China; 2. Tianjin Beichen District Chinese Medicine Hospital, Tianjin 300400, Chin)

机构地区：[1]省部共建电工装备可靠性与智能化国家重点实验室(河北工业大学),天津300130 [2]天津市北辰中医医院,天津300400

出　　处：《中国医学物理学杂志》2018年第2期228-235,共8页Chinese Journal of Medical Physics

基　　金：国家自然科学基金(31400844,51377045,61571180);河北省自然科学基金(E2016202128)

摘　　要：脑功能网络是揭示大脑精神活动的重要体现,对于亚健康失眠的脑网络分析具有重要意义。利用格兰杰因果关系算法建立脑功能有向网络实现了各级脑电之间的有向信息连通,更是对失眠基于脑电的探究。本文利用Neuroscan128导脑电实验仪采集9名失眠被试的32导脑电信号,然后基于格兰杰因果关系方法计算32导脑电极在时间序列上的有向连接关系,同时运用贝叶斯信息准则和F统计量检验每个连接值的统计显著性,再利用磁刺激穴位的方法刺激失眠被试,获得不同状态下脑功能网络的有向连接图,并对其进行分析。结果表明,磁刺激神门、内关和三阴交穴后较刺激前,大脑额叶、中央区和左颞叶内部以及脑区之间的连接有所增加;而枕叶、右颞叶内部以及脑区之间的连接有所减少。磁刺激穴位治疗亚健康失眠具有重要的研究意义,本研究得到的相应结果为其提供依据。Brain functional network reveals the mental activity of the brain, and has important significance for the brain network analysis of sub-health insomnia. Using Granger causality algorithm to establish brain functional directed network achieves the connectivity of the directional information within the electroencephalogram（EEG） at all levels, and realizes the EEG analysis for insomnia. Neuroscan of 128 channels was applied to collect the 32-channel EEG signals of 9 subjects who were in insomnia. The directional and connected relationship on the time sequence of 32-channnel EEG electrodes were calculated based on Granger causality, and simultaneously, Bayesian information criterion and F-statistics were used to examine the statistic significance of every connected value. Finally, we analyzed the connection diagrams of brain functional networks under different states which were obtained by stimulating insomnia subjects with magnetic stimulation at acupoints. The results revealed that the connections were increased between the frontal, centralis, left temporal lobe and encephalic regions, at the same time, the connections were decreased between the occipital lobe, right temporal lobe and encephalic regions after magnetic stimulating Shenmen, Neiguan and Sanyinjiao. Magnetic stimulation at acupoints for subhealth insomnia has important research significance, and the corresponding results obtained in this research provide the basis for the further research.

关 键 词：失眠 脑功能网络 格兰杰因果关系 贝叶斯信息准则 磁刺激穴位 

分 类 号：R35[医药卫生—基础医学]