急性脑梗死患者神经功能缺损程度与血清H-FABP、CD62P水平的关系  

The relationship between the degree of neurological impairment of patients with acute cerebral infarction and expression level of H-FABP and CD62P in serum

作　　者：吴芳 刘悦 蔡志友[2] Wu Fang , Liu Yue, Cai Zhiyou(Department of Neurolo- gy, Chongqing Three Gorges Central Hospital ,Chongqing 40400)

机构地区：[1]重庆市三峡中心医院神经内科,404000 [2]重庆市第三人民医院

出　　处：《卒中与神经疾病》2018年第2期142-145,149,共5页Stroke and Nervous Diseases

摘　　要：目的探讨急性脑梗死患者神经功能缺损程度与血清心型脂肪酸结合蛋白(H-FABP)、血小板α颗粒膜蛋白(CD62P)的关系。方法选择本院收治的180例急性脑梗死患者为研究对象,将其分为轻度组、中度组、重度组3组,每组各60例,以同期体检健康者60例为对照组;采用神经功能缺损评分量表(NIHSS评分)评定急性脑梗死患者神经功能缺损程度,通过酶联免疫吸附法(ELISA)检测各组血清神经功能缺损指标(NES、S100B)及H-FABP、CD26P水平,分析神经功能缺损程度与血清H-FABP、CD26P的关系。结果急性脑梗死重度组与中度组NIHSS评分、NES及S100B水平均高于急性脑梗死轻度组,而中度组高于轻度组(P<0.01);急性脑梗死组血清H-FABP、CD26P水平均高于对照组,急性脑梗死重度组与中度组高于急性脑梗死轻度组,而中度组血清H-FABP、CD26P水平高于轻度组(P<0.01);急性脑梗死患者血清H-FABP、CD26P水平与神经功能缺损程度呈正相关。结论急性脑梗死患者神经功能缺损程度与血清H-FABP、CD26P水平呈显著正相关,推测临床可参照血清H-FABP、CD26P水平来评估急性脑梗死患者神经功能缺损程度。Objective To explore the relationship between the degree of neurological impairment in patients with acute cerebral infarction and expression level of H-FABP and CD62 P in serum. Methods 180 patients with acute cerebral infarction in hospital were divided into three groups,namely mild group（ n = 60）,moderate group（ n =60） and severe group（ n = 60）,meanwhile 60 cases of healthy physical examination in the same period constituted the control group. The neural function defect scale scale（ NIHSS score） was used to assess neurologic deficits degree of acute cerebral infarction patients,and the expression levels of NES,S100 B,H-FABP and CD26 P in serum were detected by enzyme-linked immunosorbent（ ELISA）. Results The NIHSS score,NES,and S100 B levels in severe group and moderate group were higher than those in mild group,and the NIHSS score,NES,and S100 B levels in moderate group were higher than those in mild group（ P〈0. 01）. The H-FABP and CD26 P expression levels in serum of patients with acute cerebral infarction were higher than those in control group,and the H-FABP and CD26 P expression levels in severe group and moderate group were higher than those in mild group,the H-FABP and CD26 P expression levels in moderate group were higher than those in mild group（ P〈0. 01）. The H-FABP and CD26 P expression levels in serum were positively correlated with the neural impairment degree of patients with acute cerebral infarction（ r = 0. 752,0. 813,P〈0. 05）. Conclusion The nerve function defect degree of patients with acute cerebral infarction was significantly positive related to H-FABP and CD26 P expression levels in serum,we speculated that the H-FABP and CD26 P expression levels in serum could be used to evaluate the neurological impairment degree of patients with acute cerebral infarction.

关 键 词：急性脑梗死 神经功能缺损程度 心型脂肪酸结合蛋白 血小板Α颗粒膜蛋白 

分 类 号：R743.3[医药卫生—神经病学与精神病学]