咖啡因在早产儿的应用及其对预后的影响  

Caffeine therapy in preterm infants and its effect on their outcomes

作　　者：杨晓燕 母得志 YANG Xiao-yan, MU De-zhi.(Department of Pediatrics, West China Second University Hospital, Sichuan University;Key Laboratory of Obstetric ＆ Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Chengdu 610041, Chin)

机构地区：[1]四川大学华西第二医院儿科出生缺陷与相关妇儿疾病教育部重点实验室,四川成都610041

出　　处：《中国实用儿科杂志》2018年第5期346-348,共3页Chinese Journal of Practical Pediatrics

基　　金：国家临床重点专科建设项目(1311200003303)

摘　　要：咖啡因是一种黄嘌呤衍生物,在体内通过非选择性地抑制腺苷受体而产生多种药理作用。在早产儿,咖啡因主要用于呼吸暂停(apnea of prematurity,AOP)的防治。研究显示,除减少AOP的发生外,咖啡因对早产儿的神经系统及呼吸系统均具有保护作用,特别是早期使用咖啡因可为早产儿带来远期的改善。因此,咖啡因在早产儿中的应用越来越受到重视,但其保护机制尚不完全清楚,有待进一步论证。As one of the xanthine derivates, caffeine could inhibit adenosine receptors in vivo non-specifically, which would lead to a series of pharmacological effects. Caffeine is the choice of treatment for apnea of prematurity （AOP）. Besides, various studies show its protection for both nervous system and respiratory system. Early caffeine administration could bring significant and long- lasting benefits for preterm infants. However, further researches are still needed to discuss the probable mechanisms.

关 键 词：咖啡因 早产儿 

分 类 号：R72[医药卫生—儿科]