Evaluation of Antibody-Dependent Enhancement of SARS-CoV Infection in Rhesus Macaques Immunized with an Inactivated SARS-CoV Vaccine  

作　　者：Fan Luo Fan-Lu Liao Hui Wang Hong-Bin Tang Zhan-Qiu Yang Wei Hou 

机构地区：[1]State Key Laboratory of Virology/Hubei Province Key Laboratory of Allergy and Immunology/Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University [2]Department of Clinical Laboratory, Zhongnan Hospital,Wuhan University [3]Center for Animal Experiment/Animal Biosafety Level-Ⅲ Laboratory, Wuhan University

出　　处：《Virologica Sinica》2018年第2期201-204,共4页中国病毒学（英文版）

基　　金：supported by the Chinese Medicine Foundation and Opening Foundation of State Key Laboratory of Virology,Wuhan University (No.2016KF010)

摘　　要：In 2003,severe acute respiratory syndrome coronavirus（SARS-CoV）emerged in Guangdong Province,China,infected more than 8000 individuals,and resulted in a 10%mortality rate（Rota et al.2003）.Later,in 2012,a novel CoV,Middle East respiratory syndrome coronavirus（MERS-CoV）,was isolated from the sputum of a man in Saudi Arabia（Perl et al.2014）.Notably,MERS-CoV recently reemerged in the Republic of Korea, and killed 36 out of 186 confirmed cases （Korea Centers for Disease Control and Prevention 2015）. Therefore, SARS-CoV still carries the potential for resurgence; efforts are being made to prevent the recurrence of an epidemic.Dear Editor,In 2003,severe acute respiratory syndrome coronavirus(SARS-CoV)emerged in Guangdong Province,China,infected more than 8000 individuals,and resulted in a 10%mortality rate(Rota et al.2003).Later,in 2012,a novel CoV,Middle East respiratory syndrome coronavirus(MERS-CoV),was isolated from the sputum of a man in Saudi Arabia(Perl et al.2014).Notably。

关 键 词：SARS-COV 感染 猕猴 活性 免疫 疫苗 评估 抗体 

分 类 号：R392[医药卫生—免疫学]