榄香烯乳注射液维持治疗对恶性胸腔积液复发时间影响的临床观察  

Clinical observation on the effect of elemene injection maintenance treatment on the recurrence time of malignant pleurai effusion

作　　者：宋爱英[1] 高飞 李雨[1] 游小晴 庞雪莹 Song Aiying, Gao Fei , Li Yu, You Xiaoqing , Pang Xueying(Department of Oncology, First Affiliated Hospital of Heilongfiang University of Traditional Chinese Medicine, Harbin 150040, Chin)

机构地区：[1]黑龙江中医药大学附属第一医院肿瘤科,哈尔滨150040 [2]黑龙江中医药大学研究生院

出　　处：《国际肿瘤学杂志》2018年第2期70-72,共3页Journal of International Oncology

摘　　要：目的 观察榄香烯乳注射液对恶性胸腔积液维持治疗的效果.方法 收集黑龙江中医药大学附属第一医院自2014年5月至2016年4月收治的恶性胸腔积液患者90例,将其按随机数字表法分为观察组和对照组,每组各45例.两组患者通过胸腔穿刺彻底引流胸腔积液,灌注甘露聚糖肽（力尔凡）及卡铂,观察组序贯榄香烯乳注射液维持治疗.对比两组患者的治疗效果.结果 治疗后第12个月,观察组和对照组复发率差异有统计学意义（82.2％∶100％,x2=8.780,P=0.003）.观察组和对照组的中位无进展生存期（95％ CI）分别为10.00（9.15～10.85）个月和6.00 （4.74～7.26）个月,差异有统计学意义（x2 =40.475,P＜0.001）.观察组在灌注治疗后第1、6、12个月生命质量改善率分别为82.22％、57.78％、54.55％,对照组分别为84.44％、23.26％、0,其中第6和第12个月生命质量改善率两组比较差异具有统计学意义（x2=10.840,P=0.001;x2=32.390,P＜0.001）.观察组和对照组1年生存率分别为97.78％、95.56％,差异无统计学意义（P=1.000）.结论 榄香烯乳注射液对恶性胸腔积液维持治疗效果明显,能延长患者无进展生存期,并能显著提高生命质量.Objective To observe the effect of elemene injection for the maintenance treatment of malignant pleural effusion.Methods A total of 90 patients with malignant pleural effusion from May 2014 to Apirl 2016 in First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine were collected.They were divided into observation group （n =45） and control group （n =45） according to the random number table method.The patients of the two groups were treated with pleural effusion drainage through thoracocentesis,and Mannatide （Lifein） and carboplatin were poured.The observation group sequentially received maintenance treatment of elemene injection.The therapeutic effects of the two groups were compared.Results At the 12th month after treatment,the difference of relapse rate between the two groups was statistically significant（82.2% vs.100.0%,x2 =8.780,P =0.003）.The median progression-free survival （95% CI） of the observation group and the control group were 10.00 （9.15-10.85） months and 6.00（4.74-7.26） months respectively,with a significant difference （x2 =40.475,P 〈 0.001）.The improvement rates of life quality of the observation group were 82.22%,57.78%,54.55% respectively at one,six,twelve months after perfusion treatment,and the improvement rates of the control group were 84.44%,23.26%,0 respectively.The data differences between the two groups were statistically significant at six,twelve months （x2 =10.840,P =0.001;x2 =32.390,P 〈 0.001）.The one year survival rates of the observation group and the control group were 97.78% and 95.56%,and the difference was statistically significant （P =1.000）.Conclusion The effect of elemene injection for the maintenance treatment of malignant pleural effusion is obvious,which can prolong the progression-free survival time and can significantly improve the quality of life.

关 键 词：胸腔积液 恶性 药物疗法 榄香烯 

分 类 号：R730.6[医药卫生—肿瘤]