Wnt通路关键信号分子与肝癌靶向治疗  

Key signal molecules of wingless-related integration pathway and targeted therapy for liver cancer

作　　者：郑文杰[1] 姚登福[1] Zheng Wenjie;Yao Dengfu(Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China)

机构地区：[1]南通大学附属医院临床医学研究中心,226001

出　　处：《中华肝脏病杂志》2018年第5期397-400,共4页Chinese Journal of Hepatology

基　　金：国家自然科学基金（81673241、81702419）;江苏省研究生科研创新计划（KYCX17_1934）;南通市卫生和计划生育委员会青年科研基金项目（WQ2016083）

摘　　要：肝细胞性肝癌（HCC）是常见的消化系统肿瘤，其发生和发展是多因素、多步骤共同作用的结果。近年来多项研究结果表明wnt通路在HCC进展中发挥重要作用，与肝细胞恶性转化、HCC转移与耐药、肝癌干细胞相关。该文分析了Wnt通路关键信号分子在HCC中的表达情况及其在诊断、预后和靶向治疗中的价值，并概述了Wnt通路靶向药物治疗HCC的研究进展，以期为HCC靶向治疗研究提供参考。Hepatocellular carcinoma is one of the most common digestive system tumors. Its occurrence and development are considered as multi-factorial and multi-step process. Recent studies have shown that wingless-related integration （Wnt） pathway plays an important role in the HCC progression and is associated with malignant transformation of hepatocytes, HCC metastasis, drug resistance and liver cancer stem cells. This article analyzes the expression of key signaling molecules in Wnt pathway and its value in diagnosis, prognosis and targeted therapy, and outlines the research progress of Wnt pathway targeted drugs for the treatment of HCC, with a view to providing targeted therapy research for HCC reference.

关 键 词：癌 肝细胞 诊断 预后 WNT通路 靶向治疗 

分 类 号：R735.7[医药卫生—肿瘤]