益气健脾方联合替吉奥一线治疗老年晚期胃癌41例  

Chinese Herbal Medicine Yiqi Jianpi Prescription combined with S-1 as first-line treatment for 41 aged cases of advanced gastric cancer

作　　者：俞根华 姚强 张海兵[3] 纪鹏天[3] 邓建良 顾贤成 YU Gen-hua1 , YAO Qiang2, ZHANG Hai-bing3 , JI Peng-tian3 , DENG Jian-liang2 , GU Xian-cheng2(1. Department of Oncology Radiology, Zhebei Mingzhou Hospital, Huzhou City, Zhefing Province, International Branch of The First Hospital of Huzhou City, Huzhou 313000, China; 2. Department of Oncology, Yixing Hospital Affiliated to the Zhejing University, Yixing 214200; 3. Department of Intervention Radiology, Central Hospital of Huzhou City, Zhejiang Province, Huzhou , 313000)

机构地区：[1]浙江省湖州市浙北明州医院(湖州市第一医院国际分院)肿瘤放疗科,湖州313000 [2]江苏大学附属宜兴医院肿瘤科,宜兴214200 [3]浙江省湖州市中心医院介入放疗科,湖州313000

出　　处：《北京中医药》2018年第4期318-320,323,共4页Beijing Journal of Traditional Chinese Medicine

摘　　要：目的观察中药益气健脾方联合替吉奥胶囊一线治疗老年晚期胃癌患者的疗效、生活质量及不良反应。方法回顾分析85例老年晚期胃癌患者,按是否口服中药分为2组,口服替吉奥胶囊对照组,口服替吉奥胶囊联合中药益气健脾方观察组;28 d为1个疗程,治疗4个疗程后评价疗效,观察患者的一般情况、各项血液学指标,并随访患者的1年生存率及总生存时间。结果 4周期治疗后对照组Karnofsky评分(KPS)改善率低于观察组,差异有统计学意义(P<0.05);对照组Ⅱ度以上中性粒细胞下降率高于观察组,差异有统计学意义(P<0.05)。2组消化道反应比较,差异无统计学意义(P>0.05);近期缓解率(CR+PR)对照组为50.0%,观察组为58.5%,差异无统计学意义(P>0.05);对照组1年生存率为61.4%,观察组为75.6%,2组比较差异无统计学意义(P>0.05);Kaplan-Meier生存曲线提示对照组中位生存时间12.6个月,观察组中位生存时间15.6个月,2组间差异有统计学意义(P<0.05)。结论益气健脾中药方剂联合替吉奥胶囊治疗老年晚期胃癌可改善患者生活质量,降低化疗的不良反应,延长患者生存时间。Objective To observe the clinical efficacy, quality of life and adverse reactions of Chinese herbal medicine Yiqi Jianpi Prescription combined with S-1 treatment for aged cases of advanced gastric cancer. Methods A total of 85 aged cases with advanced gastric cancer were retrospectively analyzed. These cases were divided into two groups. The control group was treated with S-1 taken orally only, and the observation group was given S-1 and Chinese herbal medicine Yiqi Jianpi Prescription orally; 28 days constituted one course. The patient＇ s general condition and hematological indexes were observed and the efficacy evaluated after 4 courses of treatment with one year following-up of survival rate and overall survival time. Results After 4 courses of treatment, Karnofsky scores （KPS） improvement rate of the control group was lower than that of the observation group, and the difference had statistical significance （ P 〈 0. 05 ） . The Ⅱ - Ⅳ neutrophil decline rate of the control group was higher than that of the observation group, and the difference had statistical significance （ P 〈 0. 05 ） . The difference of digestive tract adverse reactions had no statistical significance between the two groups and the difference had no statistical significance （ P 〉 0. 05 ） . The recent remission rate（ CR ＋ PR） of the control group and the observation group were 50. 0% and 58.5% respectively, and the difference had no statistical significance （ P 〉 0. 05 ） . The one year survival rate between the two groups （61.4% , 75.6% ） also had no statistical significance （P 〉 0. 05 ） . Kaplan-Meier survival curve demonstrated that median survival time of the control group was 12. 6 month and that of the observation group was 15.6 months, and the difference was statically significant （ P 〈 0. 05 ） . Conclusion Chinese Herbal Medicine Yiqi Jianpi Prescription combined with S-I taken oral could improve the quality of life, reduce the adverse reactions caused by chemotherapy and prolong th

关 键 词：老年患者 晚期胃癌 替吉奥 中药 生活质量 

分 类 号：R735.2[医药卫生—肿瘤]