补肾益智汤联合卡巴拉汀治疗阿尔兹海默症临床效果及对血清缓激肽水平的影响  

Effects of Bushen Yizhi Decoction Combined with Heavy Tartaric Acid Carberlatin Hydrochloride in Treatment of Patients with Alzheimer’s Disease and Influence on Serum Bradykinin

作　　者：亓爱芹[1] 朱峻岭[1] 吕立峰[1] 李秀芹[1] QI Aiqin, ZHU Junling, LYU Lifen, LI Xiuqin(Department of Neurology, Laiwu People＇ s Hospital, Laiwu 271100, Shandong, Chin)

机构地区：[1]莱芜市人民医院神经内科

出　　处：《中华中医药学刊》2018年第5期1252-1255,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：莱芜市卫生局科研基金项目(莱科鉴字[2012]030)

摘　　要：目的：观察补肾益智汤联合卡巴拉汀治疗阿尔兹海默症的临床效果及对血清缓激肽水平的影响。方法：选择医院收治的70例符合入组标准的阿尔兹海默症患者作为研究对象,按随机数字表分为研究组（35例）和对照组（35例）,对照组患者给予卡巴拉汀治疗,研究组在对照组的基础上再口服补肾益智汤,4周为1个疗程,两组均治疗6个疗程,治疗前后进行中医症候积分、简易智能状态量表（mini-mantal state examination,MMSE）评分、修订韦氏记忆量表（WMS）、痴呆量表（Blessed-Roth）评分、阿尔兹海默症评定量表（ADAS-Cog）评分、日常生活能力量表（ADL）评分评判,取清晨空腹血,采用生物素双抗体夹心酶联免疫吸附法进行血清缓激肽（BK）检测,评价中医临床疗效,记录不良反应发生情况。结果：研究组治疗后记忆力减退、腰膝酸软、倦怠嗜卧、表情呆钝、善惊易恐、脑转耳鸣、面颊潮红等中医症候积分均较治疗前明显下降（P〈0.05）,而对照组仅记忆力减退明显改善（P〈0.05）。研究组和对照组治疗后MMSE、WMS明显升高（P〈0.05）,ADL、Blessed-Roth、ADAS-Cog明显降低（P〈0.05）,且研究组治疗后MMSE、WMS明显高于对照组（P〈0.05）,ADL、Blessed-Roth、ADAS-Cog明显低于对照组（P〈0.05）。研究组和对照组治疗后BK均明显降低（P〈0.05）,研究组治疗后BK明显低于对照组（P〈0.05）。研究组的中医临床疗效总有效率为82.86%,明显高于对照组62.86%,差异具有统计学意义（P〈0.05）。结论：阿尔兹海默症在卡巴拉汀治疗的基础上再加用补肾益智汤治疗的临床疗效明显,能有效改善患者认知功能、记忆功能、痴呆程度及日常生活能力,可能与其降低血清血清缓激肽水平有关。Objective： To investigate the effects of Bushen Yizhi Decoction combined with heavy tartaric acid carberlatin hydrochloride in the treatment of patients with Alzheimer＇s disease and the influence on serum bradykinin. Methods：Seventy patients with Alzheimer＇s disease who met the inclusion criteria in our hospital were divided into the study group（n = 35） and the control group（n = 35） according to the random number table. The control group were treated with rivastigmine capsules and the study group were treated with Bushen Yizhi Decoction on the basis of the control group,4 weeks for a course of treatment. Both groups had been treated for 6 courses. Then the Chinese medicine syndrome score,mini mental state table MMSE,WMS,blessed Roth,ADAS COG,ADL and serum BK levels were detected and compared between the two groups before and after treatment. The clinical efficacy of traditional Chinese medicine was evaluated and the occurrence of adverse reactions was recorded. Result： The Chinese medicine syndrome scores of Memory loss,Yaoxisuanruan,tired addiction,expression blunt,good fear of fear,brain to tinnitus and cheek flushing in the study group after treatment were lower than those before treatment（P〈0. 05）. But the control group had only a significant improvement in memory loss（P〈0. 05）. The MMSE and WMS in the study group and the control group after treatment were higher than those before treatment（P〈0. 05）. The ADL,Blessed-Roth and ADAS-Cog were significantly decreased after treatment（P〈0. 05）. The MMSE and WMS in the study group after treatment were higher than those of the control group（P〈0. 05）. The ADL,Blessed-Roth and ADAS-Cog were significantly lower than those in the control group（P〈0. 05）. The BK in both group after treatment was significantly lower than those before treatment（P〈0. 05）. The BK of the study group after treatment was significantly lower than that of the control group（P〈0. 05）. The total effective rate of the clinical efficacy of

关 键 词：阿尔兹海默症 补肾益智汤 临床疗效 缓激肽 

分 类 号：R749.16[医药卫生—神经病学与精神病学]