Lactonization of C（sp2）-H Bonds in Enamides with CO2  

作　　者：Zhen Zhang Chun-Jun Zhu Meng Miao Jie-Lian Han Tao Ju Lei Song Jian-Heng Ye Jing Li Da-Gang Yu 

机构地区：[1]College of Pharmacy and Biological Engineering, Chengdu University, Chengdu, Sichuan 610106, China [2]Key Laboratory of Green Chemistry & Technology of Ministry of Educa- tion, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China [3]State Key Laboratory of EJemento-Organic Chemistry, Nankai University, Tianjin 300071, China

出　　处：《Chinese Journal of Chemistry》2018年第5期430-436,共7页中国化学（英文版）

摘　　要：Herein, we report a novel synthesis of 1,3-oxazin-6-ones from enamides with CO2 through C--H carboxylation and one-pot cyclization. This transition-metal-free and redox-neutral process features broad substrate scope, good functional group tolerance and facile product derivatization. The nucleophilic attack to CO2 from the electron-rich alkene is demonstrated for this reaction.Herein, we report a novel synthesis of 1,3-oxazin-6-ones from enamides with CO2 through C--H carboxylation and one-pot cyclization. This transition-metal-free and redox-neutral process features broad substrate scope, good functional group tolerance and facile product derivatization. The nucleophilic attack to CO2 from the electron-rich alkene is demonstrated for this reaction.

关 键 词：carbon dioxide transition-metal-free LACTONIZATION 1 3-oxazin-6-ones 

分 类 号：O613.71[理学—无机化学] TV73[理学—化学]