小型猪肝脏局部碘化油微环境对微波消融灶的影响  

Impact of local lipiodol deposition in liver on necrotic area after microwave ablation in miniature pigs

作　　者：鲍婷婷 王健[1] 李真真[1] 曹守金 张杨[1] 林乐涛 宋莉[1] 佟小强[1] 邹英华[1] BAO Tingting;WANG Jian;LI Zhenzhen;CAO Shoujin;ZHANG Yang;LIN Letao;SONG Li;TONG Xiaoqiang;ZOU Yinghua(Department of htterventional Radiology and Vascular Surgeu,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院介入血管外科,北京100034

出　　处：《中国介入影像与治疗学》2018年第5期291-294,共4页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的探讨小型猪肝组织碘化油微环境对相应区域微波消融灶形态和大小的影响。方法选取10只小型猪随机分为实验组和对照组,每组各5只,对实验组动物于经肝动脉碘化油肝叶栓塞后再行微波消融,对照组直接行常规微波消融。消融后即刻进行CT检查,测量消融灶最大长轴直径(LAD)和最大短轴直径(SAD),计算其球形指数(SI,SI=SAD/LAD)和体积,并比较两组间的差异。结果消融后,实验组LAD、SAD、SI及体积分别为(4.21±0.52)cm、(2.87±0.38)cm、0.69±0.10及(18.72±6.08)cm^3,对照组分别为(3.71±0.42)cm、(2.19±0.42)cm、0.60±0.09及(9.44±2.29)cm^3,2组间差异均有统计学意义(P均<0.05)。结论小型猪局部肝组织碘化油微环境可使该区域产生更大、更近似于球形的微波消融灶。Objective To explore the impact of local lipiodol deposition in liver of miniature pigs on the shape and size of the necrotic area after microwave ablation（MWA）.Methods Ten healthy miniature pigs were selected and equally divided into experimental group and control group（each n=5）.In experimental group,transcatheter hepatic arterial embolization with lipiodol was done before microwave ablation,while only standard microwave ablation was performed in control group.Immediate post-ablation CT images were obtained.Long-axis diameter（LAD）,short-axis diameter（SAD）,sphericity index（SI=SAD/LAD）and volume of ablation zone were calculated.The size and shape of the ablated areas were compared between two groups.Results The mean LAD,SAD,SI and volume of ablation zone in experimental group（[4.21±0.52]cm,[2.87±0.38]cm,0.69±0.10,[18.72±6.08]cm3）were larger than those in control group（[3.71±0.42]cm,[2.19±0.42]cm,0.60±0.09,[9.44±2.29]cm^3;all P〈0.05）.Conclusion Local deposition of lipiodol in liver parenchyma of miniature pigs can help to produce larger and rounder necrosis in the ablation zone.

关 键 词：碘化油 体层摄影术 X线计算机 肝肿瘤 化学栓塞 治疗性 热沉效应 微波消融 

分 类 号：R364.26[医药卫生—病理学] R814.42[医药卫生—基础医学]