缓解期的精神分裂症患者及其一级非患病亲属的认知功能比较分析  

Cognitive function of remitted schizophrenia patients and their first-degree non-psychotic relatives

作　　者：冯映映 胡晓华[1] 田艳[1] 江云[1] 王宗琴[1] 高作惠[1] 包玲[1] FENG Yingying , HU Xiaohua , TIAN Yan , JIANG Yun ,WANG Zongqing , GAO Zuohui , BAO Ling(Wuhan Mental Health Center, Tongji Medical College, Huazhong University of Science and Technology ,Wuhan , Hubei 430022, Chin)

机构地区：[1]华中科技大学同济医学院附属武汉精神卫生中心,武汉430022

出　　处：《重庆医学》2018年第13期1740-1742,1745,共4页Chongqing medicine

基　　金：2013年度湖北省武汉市卫生和计划生育委员会公共卫生科研项目(WG13B07)

摘　　要：目的了解缓解期精神分裂症患者及一级非患病亲属的认知功能,找寻认知功能中具有内表型特征的项目。方法对86名缓解期精神分裂症患者(患者组),86名患者的一级非患病亲属(亲属组)及86名健康人(对照组)使用精神分裂症认知功能成套测验工具进行认知功能测验。结果患者组和亲属组的连线测验、符号编码、霍普金斯词语学习测验、迷宫、流畅性、情绪智商和持续操作性得分低于对照组(P<0.05)。患者组霍普金斯词语学习测验、迷宫、情绪智商和持续操作性得分低于亲属组(P<0.05)。结论缓解期患者和其一级非患病亲属的认知功能存在选择性缺陷,其中词语学习、注意/警觉、推理和问题解决及社会认知可能是精神分裂症潜在的内表型。Objective To explore difference of neuropsychological tests between the remitted schizophrenia patients and the first-degree non-psychotic relatives of schizophrenia patients, and to explore the possible endophenotypes in cognitive function. Methods The MATRICSTM consensus cognitive battery was administered to 86 remittent schizophrenia patients （the patient group） ,86 first-degree non-psychotic relatives of schizophrenia patients （the relative group）, and 86 healthy people （the control group）. Results Compared with the control group, the patients group and the relative group showed poor performance on trail making test, brief assessment of cognition, hopkins verbal learning, mazes; category fluency, emotional intelligence test and continuous performance test （P〈0.05）. There were significantly lower performances in the patient group than the relative groups on hopkins verbal learning, mazes, emotional intelligence test and continuous performance test （P〈0.05）. Conclusion The remitted schizophrenia patients and their first-degree non, psychotic relatives have selective deficits in cognition function, among them, verbal leaning, attention/vigilance, reasoning and problem solving and social cognition may be potential endophenotypes for schizophrenia.

关 键 词：精神分裂症 认知 一级非患病亲属 缓解期 内表型 

分 类 号：R749.3[医药卫生—神经病学与精神病学]