CTRP1在急性缺血性脑卒中患者中的表达及其对晚期神经功能缺损严重程度的预测  

The expression of C1q/TNF-related protein-1 in patients with acute ischemic stroke and its predictive value for the severity of neurological deficits

作　　者：李素萍[1] 谢彦 许飞[1] 梁益[1] 何保明[1] 孙红斌[1] LI Suping;XIE Yan;XU Fei;LIANG Yi;HE Baoming;SUN Hongbin(Department of Neurology Sichuan Provincial People′s Hospital,Chengdu 610072,China)

机构地区：[1]四川省医院科学院.四川省人民医院神经内科,成都610073

出　　处：《实用医学杂志》2018年第10期1672-1675,共4页The Journal of Practical Medicine

基　　金：四川省卫生和计划生育委员会科研项目(编号:17PJ078)

摘　　要：目的探讨补体Cq1/肿瘤坏死因子相关蛋白(CTRP1)在急性缺血性脑卒中(AIS)患者中的表达及其对晚期神经功能缺损严重程度的预测价值。方法选取2014年2月至2017年2月首次发生AIS患者452例作为脑卒中组,选取同期来医院进行健康体检者403例作为对照组。采用美国国立卫生研究院卒中量表(NIHSS)对患者出院后6个月时神经功能状况进行评估。采用酶联免疫吸附试验检测患者血浆中CTRP1的表达量,采用多元线性回归分析6个月神经功能缺陷和CTRP1的关系。结果对照组[(119.53±17.62)ng/mL]、不明原因及其他原因型脑卒中[(145.81±18.96)ng/mL]、大动脉粥样硬化型脑卒中[(153.17±19.21)ng/mL]、心源型脑卒中[(156.56±20.96)ng/mL]和小动脉闭塞型脑卒中[(169.23±22.34)ng/mL]的CTRP1表达水平逐渐升高,并且差异具有统计学意义(P<0.001)。对照组[(119.53±17.62)ng/mL]、神经功能缺损轻度组[(156.29±19.86)ng/mL]、中度组[(168.74±18.53)ng/mL]和重度组[(175.96±19.15)ng/mL]患者血清CTRP1水平逐渐上升,差异具有统计学意义(P<0.001)。多元线性回归分析显示,CTRP1、年龄、糖尿病、高敏C反应蛋白、低密度脂蛋白胆固醇为IS患者出院6个月后神经功能缺陷的独立影响因素。结论 CTRP1能够有效预测AIS患者晚期神经功能缺损严重程度。Objective To investigate the expression of C1q/TNF-related protein-1（CTRP1）in patientswith acute ischemic stroke and its predictive value for the severity of neurological deficits. Methods A total of452 patients with newly diagnosed ischemic stroke（IS）from February 2014 to February 2017 in our hospital wereselected as the study subjects,and 403 healthy subjects were selected as control group in the physical examinationcenter. The National Institutes of Health Stroke Scale（NIHSS）was used to evaluate the neurological status of pa-tients at admission and at 6 months after discharge. The expression of CTRP1 in plasma was detected by enzyme-linked immunosorbent assay（ELISA）. Multiple linear regression was used to analyze the relationship between neu-rological deficit and CTRP1. Results The expression level the CTRP1 in the healthy control group[（119.53±17.62）ng/m L],unexplained causes IS[（145.81±18.96）ng/m L],large atherosclerotic IS[（153.17±19.21）ng/m L],cardiac IS[（156.56±20.96）ng/m L]and small artery occlusion IS[（169.23±22.34）ng/mL]in-creased gradually with statistically significant difference（P〈0.05）. The level of CTRP1 in the healthy controlgroup[（119.53±17.62）ng/mL],mild neurologic impairment group[（156.29±19.86）ng/mL],moderate neuro-logic impairment group[（168.74±18.53）ng/m L]and severe neurologic impairment group[（175.96±19.15）ng/m L]increased gradually with statistically significant difference（P〈0.05）. Multiple linear regression analysisshowed that CTRP1,age,diabetes,Hs-CRP and LDL-C were independent factors of neurological deficits at 6 months after discharge in IS patients. Conclusion CTRP1 can effectively predict the severity of neurological defi-cits in patients with acute IS.

关 键 词：补体Cq1/肿瘤坏死因子相关蛋白1 急性缺血性脑卒中 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学]