乳铁蛋白联合锌制剂在寻常型痤疮治疗中的影响及意义  

Effects and significance of lactoferrin combined with zinc in the treatment of acne vulgaris

作　　者：张胜逆[1] 冯元冲 彭鑫宇[3] 张涛[3] ZHANG Shengni;FENG Yuanchong;PENG Xinyu;ZHANG Tao(Department of Dermatology Affiliated Hospital of Hebei University,Baoding 071000,China)

机构地区：[1]河北大学附属医院皮肤科,河北保定071000 [2]河北大学医学部,河北保定071002 [3]河北大学附属医院胃肠外科,河北保定071000

出　　处：《实用医学杂志》2018年第10期1698-1701,共4页The Journal of Practical Medicine

基　　金：2015年河北省临床重点专科培育项目(编号:冀卫医函2015-14号)

摘　　要：目的评估乳铁蛋白(LF)联合锌制剂在痤疮治疗中的作用。方法收集我院皮肤科门诊2016年3月至2017年2月126例轻中度痤疮患者,并分为观察组和对照组。治疗前后检测血清锌、白细胞介素-1β(IL-1β)、白细胞介素-17(IL-17)水平,比较观察组与对照组皮损情况、痤疮整体严重度评分标准(EGSS)、治疗效果进行评价。结果治疗前观察组和对照组血清锌浓度分别为(10.12±1.75)μmol/L、(10.35±1.68),两组间差异无统计学意义(P=0.09)。8周后观察组血清锌水平为(15.09±1.336)μmol/L,对照组为(9.98±1.26)μmol/L,差异有统计学意义(t=2.41,P=0.022)。治疗前观察组血清IL-1β、IL-17浓度分别为(1.935±0.023)pg/mL、(3.68±0.08)pg/mL;对照组分别为(1.897±0.032)pg/mL、(3.71±0.06)pg/mL,两组间比较差异无统计学意义(P=0.16,0.21)。治疗8周后观察组血清IL-1β、IL-17水平分别为(1.327±0.032)pg/mL、(2.48±0.06)pg/mL;对照组分别为(1.902±0.028)pg/mL、(3.62±0.04)pg/mL,差异有统计学意义(P=0.015、0.0011);第4周起EGSS评分与治疗前相比降低,差异有统计学意义(P<0.05)。治疗8周时观察组EGSS评分(1.73±1.23)较对照组(2.29±2.77)明显降低(t=2.51,P=0.006)。观察组总有效率为83.3%,对照组总有效率为62.2%,痊愈率观察组为45.0%,对照组为28.3%,两组相比差异有统计学意义。结论 LF和口服补锌联合应用后患者血清中锌水平上升、IL-1β、IL-17水平降低,痤疮EGSS评分改善明显。LF和口服补锌联合应用是治疗痤疮的探索性手段。Objective To determine the efficacy and safety of lactoferrin combined with zinc for mild tomoderate acne vulgaris. Methods A total of 126 patients with mild and moderate acne were randomly divided intothe trial and control groups. The levels of serum zinc,IL-1 and IL-17 were detected before and after treatment. Theskin lesions,the EGSS and therapeutic effect were compared between the two groups. Results Before treatment,the level of zinc in the trial group and the control group was（10.12±1.75）μmol/L and（10.35±1.68）μmol/L,respectively（P=0.09）. After 8 weeks,the level of zinc in the trial group was（15.09±1.336）μmol/L,and thecontrol group was（9.98±1.26）μmol/L,with statistically significant difference（t=2.41,P=0.022）. Beforetreatment,the level of IL-1 and IL-17 in the trial group were（1.935±0.023）pg/mL and（3.68±0.08）pg/mL,whereas in the control group were（1.897±0.032）pg/mL and（3.71±0.06）pg/mL,respectively（P=0.16,0.21）. After 8 weeks of treatment,the trial group IL-1β,serum IL-17 levels were（1.327±0.032）pg/mL and（2.48±0.06）pg/mL;the control group respectively（1.902±0.028）pg/mL and（3.62±0.04）pg/mL（P=0.015,0.0011）;the fourth week EGSS score had statistical significance（P〈0.05）. At 8 weeks,the score ofEGSS was significantly lower than that of the control group（t=2.51,P=0.006）. The total effective rate and re-covery rate was significantly between the two groups. Conclusions This study showed that intake of lactoferrinwith zinc can significantly reduce the level of IL-1β and IL-17,improve the severity of acne lesions in people withacne vulgaris. These data supported the potential use of lactoferrin as a safe and effective alternative or adjunct ther-apy to standard acne treatments.

关 键 词：寻常型痤疮 血清锌 乳铁蛋白 白细胞介素-1β 白细胞介素-17 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]