过表达HIF-1α和VEGF蛋白与垂体腺瘤侵袭行为的关系  

The relationship between overexpression of HIF-1α and VEGF in pituitary adenomas and their relation with invasion of pituitary adenoma

作　　者：郑杰[1] 宋来君[2] Zheng Jie;Song Laijun(First Department of Neurosurgery,Xinxiang Central Hospital,Henan Xinxiang 453000,China;Department of Neurosurgery,the First Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450052,China.)

机构地区：[1]新乡市中心医院神经外科一,河南新乡453000 [2]郑州大学第一附属医院神经外科,河南郑州450052

出　　处：《现代肿瘤医学》2018年第12期1845-1848,共4页Journal of Modern Oncology

摘　　要：目的:探讨缺氧诱导因子-1α(HIF-1α)和血管内皮生长因子(VEGF)在垂体腺瘤中的表达及与垂体腺瘤侵袭性的关系。方法:收集的32例垂体腺瘤标本中侵袭性垂体腺瘤20例,非侵袭性垂体腺瘤12例,应用免疫组化染色检测HIF-1α和VEGF蛋白的表达。并对侵袭组与非侵袭组的HIF-1α和VEGF蛋白表达及不同大小肿瘤HIF-1α和VEGF蛋白表达进行分析比较。结果:非侵袭组垂体腺瘤中HIF-1α和VEGF蛋白表达阳性率与侵袭组比较,差异有统计学意义(P<0.05);垂体腺瘤直径大于30 mm者HIF-1α和VEGF蛋白表达阳性率与直径10~30 mm者比较,差异有统计学意义(P<0.05)。结论:HIF-1α和VEGF蛋白在侵袭性垂体腺瘤中的表达明显增加,并且与垂体腺瘤侵袭行为密切相关。Objective： To explore the protein expression of hypoxia-inducible fator-1α and VEGF in pituitary adenoma and their relation with invasion of pituitary adenoma. Methods： Among the collected data of 32 cases of pituitary adenoma,20 cases were invasive pituitary adenoma and 12 cases were non-invasive pituitary adenoma.Immunochemistry staining was used to determine the protein expression of HIF-1α and VEGF.Protein expression of invasive pituitary adenoma group and non-invasive pituitary adenoma group and the protein expression of HIF-1α and VEGF in pituitary adenomas with different size were analyzed and compared. Results： The positive rate of protein expression of HIF-1α and VEGF in invasive pituitary adenomas group showed statistically significant compared with that of the non-invasive pituitary adenomas group（ P 〈0.05）.The positive rate of protein expression of HIF-1α and VEGF in pituitary adenomas with diameter larger than thirty mm showed statistically significant compared with those with diameters between ten mm to thirty mm（ P 〈0.05）. Conclusion： There were overexpression of HIF-1α and VEGF in pituitary adenomas,and these studies that the activation of HIF-1α and VEGF protein can increase the invasion of pituitary adenomas.

关 键 词：缺氧诱导因子-1Α 血管内皮生长因子(VEGF) 垂体肿瘤 

分 类 号：R736.4[医药卫生—肿瘤]