结直肠癌PRL-3蛋白表达与临床关系的Meta分析  

PRL-3 expression and its clinicopathological significance in colorectal cancer:Meta-analysis

作　　者：王旖 杨贤[1] 王宏坤[2] 郑绘霞[2] 梁建芳[1] Wang Yi;Yang Xian;Wang Hongkun;Zheng Huixia;Liang Jianfang(The First Clinical Medical College,Shanxi Medical University,Shanxi Taiyuan 030001,China;Department of Pathology,the First Hospital of Shanxi Medical University,Shanxi Taiyuan 030001,China.)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]山西医科大学第一医院病理科,山西太原030001

出　　处：《现代肿瘤医学》2018年第12期1870-1876,共7页Journal of Modern Oncology

摘　　要：目的:研究促肝再生磷酸酶蛋白(PRL-3)在结直肠癌患者癌组织中的表达与临床病理特征的相关性。方法:检索知网、万方、和pubmed、Web of science、EMBASE等数据库以"PRL-3,结直肠癌"为主要检索词收集从2000年至2017年1月1日,国内外公开发表的关于PRL-3和结直肠癌临床病理特征关系的相关文献,对文献筛选和评价,符合标准的文献用RevM an5.3分析软件进行Meta分析。结果:最终纳入16篇文献,共包括1 489例病例,835例正常对照。PRL-3蛋白在结直肠癌组的表达与年龄、性别差异无统计学意义(P>0.05)。PRL-3蛋白在正常大肠黏膜组织的表达低于结直肠癌组(I^2=12%,P<0.000 01,OR=4.01);PRL-3蛋白在高分化的结直肠癌组的表达低于中、低分化组(OR=1.45,P=0.03,I^2=39%);PRL-3蛋白在未超过浆膜层组的表达低于侵及或超过浆膜层组(OR=2.36,P=0.01,I^2=61%);PRL-3蛋白在无淋巴结转移组的表达低于有转移组(OR=3.74,P<0.000 01,I^2=54%),采用随机效应模型进行Meta分析;PRL-3蛋白在不伴有肝转移组的表达低于有肝转移组(OR=2.88,P<0.000 1,I^2=36%);PRL-3蛋白在Ⅰ+Ⅱ期组的表达低于Ⅲ+Ⅳ期组(OR=7.97,P<0.000 01,I^2=28%)。结论:PRL-3参与了结直肠癌发生、发展、转移过程,是预后不良的指征。Objective： To investigate the correlation of the expression phosphatase of regenerating liver-3 and clinicopathological features. Methods： Systematic computerized searches of CNKI,Wanfang,Cqvip,CBMdisc,PubMed,Web of science,EMBASE,Wiley Online Library databases meeting specified search criteria were peformed from year 2000 to Jan.1 2017,with ＂PRL-3,colorectal cancer＂as key words,followed by a further screening according to inclusive and exclusive criteria,and the data meeting the selected standard were carried out by Revman5.3. Results： Sixteen reports were selected based on the standard,including 1 489 patients with colorectal cancer and 835 cases with normal controls.Expression of PRL-3 in colorectal cancer and age,gender,the difference was no significant（P〉0.05）.The level of PRL-3 in colorectal cancer higher in normal colonic mucosa （I^2=12%,P〈0.00001,OR=4.01）.The level of PRL-3 in moderately and poorly differentiated cancer were higher than well differentiation（OR=1.45,P=0.03,I^2=39%）.The level of PRL-3 in colorectal cancer with the invased subserosa higher muscularis and serosal layer（OR=2.36,P =0.01,I^2=61%）.The expression of PRL-3 in colorectal cancer with lymph node metastasis was higher than without metastasis （OR=3.74, P〈0.00001,I^2 =54%）,so random effects model to merge was used.The expression of PRL-3 in Colorectal Cancer with liver metastasis was higher than without metastasis （OR=2.88, P〈0.000 1,I^2 =36%）.The level of PRL-3 in Ⅲ＋Ⅳ of TNM stage was higher than ⅠandⅡstage （OR=7.97,P〈0.00001,I^2 =28%）. Conclusion： PRL-3 expression in the incidence,development and metastasis of colorectal cancer is positively associated with the malignancy of the tumor and may be a sign of poor prognosis.

关 键 词：PRL-3 结直肠癌 META分析 

分 类 号：R735.3[医药卫生—肿瘤]