多中心型Castleman病临床病理分析并文献复习  

Clinicopathologic analysis of multicentric Castleman disease and review of the literature

作　　者：张玉[1] 景彩萍[1] 赵雪艳[1] 张桃桃[1] 霍媛媛[1] 张冠军[2] Zhang Yu;Jing Caiping;Zhao Xueyan;Zhang Taotao;Huo Yuanyuan;Zhang Guanjun(Department of Pathology,People＇s Hospital of Yan＇an,Shaanxi Yan＇an 716000,China;Department of Pathology,the First Affiliated Hospital of Medical College of Xi＇an Jiaotong University,Shaanxi Xi＇an 710061,China.)

机构地区：[1]延安市人民医院病理科,陕西延安716000 [2]西安交通大学第一附属医院病理科,陕西西安710061

出　　处：《现代肿瘤医学》2018年第12期1896-1899,共4页Journal of Modern Oncology

摘　　要：目的:探讨多中心型Castleman病(multiple Castleman disease,MCD)的临床表现、病理学特征、鉴别诊断、病因及治疗,并分析其预后。方法:对9例多中心型Castleman病的临床资料、病理形态学特征进行分析,并行免疫组化检测及相关文献复习。结果:9例多中心型Castleman病例中,透明血管型5例,浆细胞型2例,透明血管浆细胞混合型2例。免疫组化无特征性表现,但可辅助诊断及鉴别诊断。9例多中心型患者均有完整随访资料,经治疗后其中有1例复发,1例死于心脏疾病,其余患者症状均有所缓解。结论:多中心型Castleman病是一种少见的淋巴组织增生性疾病,临床易与其他疾病相混淆,确诊需依靠病理学检查,准确的临床分型和病理类型对患者的治疗和预后具有重要意义。Objective： To investigate the clinic-pathologic features,differential diagnosis,etiology,treatment of multicentric Castleman disease,and analyze their prognosis. Methods： Retrospective analysis of the clinical features,pathological morphology,immunohistochemistry were conducted in 9 cases of multicentric Castleman disease and reviewed of literature. Results： There were 5 cases of hayline vascular types,2 cases of plasmatcyic type and 2 cases of mixed type in all multicentric Castleman disease. Immunohistochemical results had not specific change,but they can assist diagnosis and differential diagnosis.9 cases had complete follow-up data,1 case recurrened after treatment,1 case died of heart disease,other multicentric cases achieved sustained remission. Conclusion： Multicentric Castlemandisease is a rare lymphoproliferative lesion,it is easily confused with other diseases,identified diagnosis is depend on pathological examination.The accuracy of clinical subtype and histopathogenic type are important for treatment and outcome.

关 键 词：多中心 CASTLEMAN病 临床病理特征 免疫组化 病因 

分 类 号：R733.4[医药卫生—肿瘤]