Killing pluripotent stem cells by BET protein inhibition  

作　　者：Shufeng Ma Ying Lin Zhili Rong 

机构地区：[1]Cancer Research Institute, School of Basic Medical Sciences, Southern Medical University

出　　处：《Science Bulletin》2018年第8期459-461,共3页科学通报（英文版）

基　　金：the support from the Department of Science and Technology of Guangdong Province(2014B020212018);the Natural Science Foundation of Guangdong(2017A030310331);the Guangzhou Science Technology and Innovation Commission(201508020120)

摘　　要：Human pluripotent stem cells(h PSCs),including embryonic stem cells(ESCs)and induced pluripotent stem cells(i PSCs),are capable of unlimited self-renewal and able to differentiate into all cell types in human body[1],providing a promising potential source for cell therapy.However,several bottlenecks need to be overcome to fully realize this potential,including teratoma risk resultingHuman pluripotent stem cells （hPSCs）, including embryonic stem cells （ESCs） and induced pluripotent stem cells （iPSCs）, are cap- able of unlimited self-renewal and able to differentiate into all cell types in human body , providing a promising potential source for cell therapy. However, several bottlenecks need to be overcome to fully realize this potential, including teratoma risk resulting from a few residual undifferentiated hPSCs among their derivative cells . A number of approaches have been developed to mitigate the tumorigenesis risk . Three classes of strategies have been pro- posed, including small molecules to selectively eliminate hPSCs, sui- cide genes and miRNA switches specifically expressed in hPSCs to induce cell death,

关 键 词：干细胞 蛋白质 MIRNA 风险源 房间 衍生物 专业版 小分子 

分 类 号：R73-36[医药卫生—肿瘤]