肺癌合并肺栓塞患者的临床表现及易患因素分析  

Analysis of clinical manifestation and predisposing factors in lung cancer patients with pulmonary embolism

作　　者：帖晓静 郎波 申凤乾 刘培杰 李宁 弋振营 徐志巧 TIE Xiaojing;LANG Bo;SHEN Fengqian;LIU Peijie;LI Ning;YI Zhenying;XU Zhiqiao(Department of Medical Oneology;Department of Respiration, Kaifeng Central Hospital, Kaifeng 475000, He＇nan, China)

机构地区：[1]开封市中心医院肿瘤内科,河南开封4750000 [2]开封市中心医院呼吸科,河南开封4750000

出　　处：《癌症进展》2018年第4期526-528,共3页Oncology Progress

摘　　要：目的分析肺癌合并肺栓塞患者的临床表现和易患因素。方法选取87例肺癌合并肺栓塞患者的病历资料(观察组)和87例肺癌患者的病历资料(对照组),对肺癌合并肺栓塞患者的主要临床表现和易患因素进行分析。结果肺癌合并肺栓塞患者活动后的主要临床症状包括呼吸困难、咳嗽、心悸、胸痛、咯血和肢体疼痛等。两组患者在有无化疗、有无合并基础疾病及病理分期方面比较,差异均有统计学意义(P<0.05);而在有无手术治疗、有无肿瘤转移及是否为腺癌方面比较,差异均无统计学意义(P>0.05)。观察组患者的D-二聚体、APTT、PT均高于对照组,差异均有统计学意义(P<0.05);而两组PLT、Hb、WBC、FIB水平比较,差异均无统计学意义(P>0.05)。结论肺癌合并肺栓塞患者活动后的主要临床表现包括呼吸困难、咳嗽、心悸、胸痛、咯血和肢体疼痛等,D-二聚体、APTT、PT较高,同时合并基础疾病、化疗和病理分期为Ⅲ~Ⅳ期是肺栓塞的易患因素。Objective To analyze the clinical manifestations and the risk factors of lung cancer patients with pulmonary embolism. Method The medical profiles of 87 patients with lung cancer combined with pulmonary embolism（study group） and another 87 patients with lung cancer（control group） were collected in the analysis to study the clinical manifestations and the risk factors of lung cancer combined with pulmonary embolism. Result The main clinical symptoms of the patients with lung cancer and pulmonary embolism after activity were dyspnea, cough, palpitations, chest pain, hemoptysis, and limb pain. There were significant differences regarding the administration of chemotherapy, presence of underlying disease and pathological staging between study group and control group, with significant difference observed（P〈0.05）, while no significant differences were observed in regard of surgery treatment, tumor metastasis and adenocarcinoma between the two groups（P〉0.05）. The D-dimer, APTT and PT of study group were higher than those of the control group, and the difference was statistically significant（P〈0.05）, but there was no significant difference in PLT,Hb, WBC and FIB between the two groups（P〉0.05）. Conclusion The main clinical symptoms of the patients with lung cancer combined with pulmonary embolism after activity are dyspnea, cough, palpitations, chest pain, hemoptysis, and limb pain, the D-dimer, APTT and PT of study group were higher, furthermore, presence of underlying diseases, chemotherapy and advanced cancer are important predisposing factors for pulmonary embolism.

关 键 词：肺癌 肺栓塞 临床表现 易患因素 

分 类 号：R734.2[医药卫生—肿瘤]