青少年女性乳腺恶性叶状肿瘤内癌的临床病理诊断陷阱分析  

Traps in clinicopathologic diagnosis of malignant phyllodes tumor of the breast in adolescent female patients with intraductal carcinoma

作　　者：秦艳[1] 陈莹[1] 周东华[1] QIN Yan, CHEN Ying, ZHOU Donghua(Department of Pathology, Foshan Maternal and Child Health Hospital Affiliated to Southern Medical University, Foshan 528000, Chin)

机构地区：[1]南方医科大学附属佛山妇幼保健院病理科,广东佛山52800

出　　处：《分子影像学杂志》2018年第2期229-232,共4页Journal of Molecular Imaging

摘　　要：目的分析青少年女性恶性叶状肿瘤内癌的诊断陷阱并进行文献复习。方法对1例青少年女性恶性叶状肿瘤内癌的临床特点、HE染色和免疫组化特点并结合文献进行分析。结果患者女性,18岁,镜下肿瘤细胞异型性十分明显,肿瘤增长速度快,易出现肿瘤坏死,在空芯针穿刺、冷冻及常规病理时,需排除纤维腺瘤和其他类型肉瘤、化生性癌等诊断,全面广泛取材及免疫组化才能做出准确的病理诊断。结论青少年女性乳腺恶性叶状肿瘤十分少见,恶性叶状肿瘤内癌更是十分罕见,提高该病临床病理特点的认识,可尽量减少误诊。Objective To analyze traps in clinicopathologic diagnosis of malignant phyllodes tumors（MPTs） of the breast in adolescent females with intraductal carcinoma and review the literatures. Methods The clinical features, HE staining and immunohistochemical features of one 18-year-old female MPT case with intraductal carcinoma were analyzed combined with literatures. Results Histologic study showed marked cellular atypia in the tumor with rapid growth rate, and tumor necrosis was frequently associated. Before the performance of core needle biopsy（CNB）, cryosurgery and routine pathological diagnosis, the diagnosis of fibroadenoma, other types of sarcoma and metaplastic carcinoma should be excluded, and a comprehensive and extensive collection of materials and immunohistochemistry is necessary in making an accurate pathological diagnosis.Conclusions MPTs of the breast in young females are rare, and MPTs in young females with intraductal carcinoma are even rarer. Therefore, improving the understanding of its clinicopathological features can reduce the risk of misdiagnosis.

关 键 词：恶性叶状肿瘤 导管原位癌 病理学 

分 类 号：R737.9[医药卫生—肿瘤]