分化型甲状腺癌术后患者首次^(131)I“清甲”治疗后对唾液腺功能的影响  

Effects of first ^(131)I treatment on salivary gland function in patients with differentiated thyroid carcinoma

作　　者：杨文定[1] 邹劲涛[1] 覃卫华[1] 覃绍超[1] 董经纬[1] YANG Wen-ding;ZOU Jin-tao;QIN Wei-hua;QIN Shao-chao;DONG Jing-wei(Liuzhou People＇s Hospital, Liuzhou Guangxi 545006, Chin)

机构地区：[1]广西柳州市人民医院,广西柳州545006

出　　处：《中国临床医学影像杂志》2018年第5期313-315,共3页Journal of China Clinic Medical Imaging

基　　金：广西壮族自治区卫生厅自筹经费科研课题(Z2013656)

摘　　要：目的:研究分化型甲状腺癌(DTC)患者首次接受大剂量^(131)I"清甲"治疗后唾液腺功能的变化情况。方法:53例DTC术后患者服用3.7 GBq的^(131)I行"清甲"治疗,于治疗前1周内及治疗后3月行唾液腺动态显像。结果 :53例DTC患者接受碘治疗后唾液腺摄取功能与治疗前无明显差异(P>0.05),排泄功能与治疗前对比明显减低(P<0.05)。53例中有14例(26.41%)出现口干症状或口干症状加重,这14例患者的唾液腺摄取功能在治疗前后无明显差异(P>0.05),排泄功能在治疗后明显减低(P<0.05)。结论:DTC术后首次大剂量^(131)I"清甲"治疗后3月唾液腺摄取功能正常,排泄功能明显受损。Objective： To study the changes of salivary gland function in patients with differentiated thyroid carcinoma（DTC） who underwent high dose ^（131）I ablative therapy for the first time. Methods： 53 patients with DTC were treated with3.7 GBq of ^（131）I. Salivary gland dynamic imaging was performed 1 week before treatment and 3 months after treatment. Results：There was no significant difference in salivary gland uptake between before and after iodine treatment in the 53 patients with DTC（P〉0.05）, but the excretory function was significantly lower after treatment than that before（P〈0.05）. Of 53 patients, 14 cases（26.41%） were with dry mouth symptoms or aggravated dry mouth symptoms. There was no significant difference in salivary gland uptake function between the 14 patients before and after treatment（P〉0.05）, but the excretory function was markedly reduced after treatment（P〈0.05）. Conclusion： The salivary gland uptake function was normal 3 months after the first high dose ^（131）I ablative treatment. But the excretion function was significantly impaired.

关 键 词：甲状腺肿瘤 唾液分泌 放射性核素显像 

分 类 号：R736.1[医药卫生—肿瘤] R817.4[医药卫生—临床医学]