环状RNA在肿瘤中的研究进展  

Research Progress of Cyclic RNA in Tumors

作　　者：王娟 宋伟国 周颖 WANG Juan;SONG Weiguo;ZHOU Ying(Department of Obstetrics and Gynecology, Anhui Provincial Hospital, Anhui Medical University, Hefei, 230001, China;Department of Obstetrics and Gynecology, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, 230001, China)

机构地区：[1]安徽医科大学附属省立医院妇产科,合肥市230001 [2]中国科学技术大学附属第一医院妇产科,合肥市230001

出　　处：《医学分子生物学杂志》2018年第3期166-170,共5页Journal of Medical Molecular Biology

基　　金：国家自然科学基金（No.81272881,81001168）,安徽省年度重点科研项目（No.1301043053）、2015年安徽省学术和技术带头人后备人选资助课题（No.2015H062）、中国科学院天然免疫与慢性疾病重点实验室开放课题（No.KLIICD-201603）、安徽省科技攻关课题（No.1704a0802151）

摘　　要：环状RNA（circular RNAs，circRNAs）是一种新发现的闭合环状内源性非编码RNA，它具有稳定性，保守性，组织特异性。近几年发现一些环状RNA是有功能的，很多环状RNA参与肿瘤的发生发展，因此，环状RNA可能作为一种新生的肿瘤标记物及治疗靶点，为肿瘤的诊断、治疗及预后提供一种新的途径。Circular RNAs （circRNAs） are newly discovered closed circular endogenous noncoding RNAs. They are stable, conserved, and tissue-specific. In recent years, some circular RNAs have been found to be functional and many are involved in the development of tumors. Therefore, circular RNAs may serve as novel tumor markers and therapeutic targets for the diagnosis, treatment and prognosis of tumors.

关 键 词：环状RNA 肿瘤 生成 转移 标记物 

分 类 号：R730[医药卫生—肿瘤]