中枢神经细胞瘤的临床特征及外科疗效分析  

Clinical characteristics of central neurocytoma and surgical outcome analysis

作　　者：陈震 周强意 李仕维[2] 张顺[2] 赵赤[2] 张晶[3] 赵赋[3] 刘丕楠[3] 王博[2] Chen Zhen1,2, Zhou Qiangyi2, Li Shiwei2, Zhang Shun2, Zhao Chi2, Zhang Jing3, Zhao Fu3, Liu Pi＇nan3, Wang Bo2(1. Department ofNeurosurgery, Lianyungang Hospital, Xuzhou Medical College, Lianyungang, Jiangsu 222002, China; 2. Department ofNeurosurgery, Beijng Tiantan Hospital, Capital Medical University, Beijing 100050, China; 3. Nerve Reconstruction Room, Beijing Neurosurgical Institute, Beijing 100050, Chin)

机构地区：[1]连云港市第一人民医院(徐州医科大学附属连云港医院)神经外科,222002 [2]首都医科大学附属北京天坛医院神经外科,100050 [3]首都医科大学北京市神经外科研究所神经重建室,100050

出　　处：《中国微侵袭神经外科杂志》2018年第4期161-164,共4页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：北京市卫生系统高层次卫生技术人才培养计划(领军人才)(编号:2014-2-008)

摘　　要：目的探讨中枢神经细胞瘤的临床特征、治疗方法及预后。方法回顾性分析31例中枢神经细胞瘤病人的临床资料,其中采用单额皮质入路切除肿瘤13例,经纵裂-胼胝体入路18例。结果肿瘤全切除28例,次全切除3例。术后脑积水症状均缓解,术后并发症包括脑室继发性血肿1例,癫疒间发作1例,肢体肌力下降1例,经治疗后好转。随访40~50个月,平均46.3个月,术后病人接受放疗12例,术后48个月复发1例。无死亡病例。结论显微外科手术切除中枢神经细胞瘤并结合立体定向放疗是有效的治疗方法。Objective To investigate the clinical features, treatment method and prognosis of patients with the central neurocytoma. Methods Clinical data of 31 patients with central neurocytoma were analyzed retrospectively, who received resection of tumors via trans-ffontal approach in 13 patients and via interhemispheric transcallosal approach in 18. Results The tumors were totally removed in 28 patients and partially in 3. The symptom of hydrocephalus in all patients was relieved. The postopertaive complications contained secondary hematoma in the ventricle in 1 patient, epilepsy in 1 and decreased muscle strength in 1, who got better after treatment. The patients were followed up for 40 to 50 months with a mean period of 46.3 months. Twelve patients received chemotherapy after surgery and 1 recurred 48 months after surgery. No death occurred. Conclusion Microsurgical resection and adjuvant stereotactic radiotherapy is an effective treatment for central neurocytomas.

关 键 词：中枢神经细胞瘤 入路 单额皮质 入路 经纵裂-胼胝体 放射治疗 

分 类 号：R739.41[医药卫生—肿瘤] R651.1[医药卫生—临床医学]