脂联素基因rs2241766位点多态性与结直肠癌风险相关性的meta分析  

Correlation of adiponectin rs2241766 gene polymorphism and colorectal cancer: a meta-analysis

作　　者：李政[1] 周天义 贺小会 谭志辉[1] 张先林[1] LI Zheng;ZHOU Tianyi;HE Xiaohui;TAN Zhihui;ZHANG Xianlin(Department of General Surgery, Affiliated Renhe Hospital of China Three Gorges University, Yichang, Hubei 443001, P. R. China)

机构地区：[1]三峡大学附属仁和医院普外科,湖北宜昌443001

出　　处：《中国普外基础与临床杂志》2018年第5期592-601,共10页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨脂联素基因rs2241766位点多态性与结直肠癌风险的相关性。方法计算机检索PubMed、Sciencedirect、Embase、Cochrane Database、OVID Medline、Springer Link、EBSCO、中国知网、维普、万方及中国生物医学数据库,筛选脂联素基因rs2241766位点多态性与结直肠癌风险相关性的病例对照研究,检索时间为建库至2017年9月,同时手工查阅检索相似文献及参考文献。由2位研究者独立进行文献筛选和资料提取。采用Review Manager 5.3软件进行meta分析,探索5种常见基因模型与结直肠癌发生的关系,计算结果以OR值及95%置信区间(95%CI)表示。结果共纳入文献10篇,包括3 460例结直肠癌患者和4 170例对照。meta分析结果显示:(1)等位基因模型,总体上等位基因模型与结直肠癌的发生有关[OR_(总体)=1.15,95%CI为(1.07,1.24),P=0.000 1],白种人中等位基因模型与结直肠癌的发生无关[OR_(白种人)=1.08,95%CI为(0.89,1.30),P=0.44],而黄种人中等位基因模型与结直肠癌的发生有关[OR_(黄种人)=1.16,95%CI为(1.08,1.26),P=0.000 1]。(2)显性基因模型:总体上显性基因模型与结直肠癌的发生有关[OR_(总体)=1.23,95%CI为(1.12,1.35),P<0.000 1],白种人中显性基因模型与结直肠癌的发生无关[OR_(白种人)=1.17,95%CI为(0.93,1.46),P=0.17],而黄种人中等位基因模型与结直肠癌的发生有关[OR_(黄种人)=1.24,95%CI为(1.12,1.37),P<0.000 1]。(3)隐性基因模型:总体[OR_(总体)=1.09,95%CI为(0.92,1.30),P=0.32]、白种人[OR_(白种人)=0.77,95%CI为(0.46,1.28),P=0.31]和黄种人[OR_(黄种人)=1.15,95%CI为(0.95,1.39),P=0.15]中,隐性基因模型与结直肠癌的发生均无关。(4)共显性基因模型:总体上共显性基因模型与结直肠癌的发生有关[OR_(总体)=1.20,95%CI为(1.10,1.32),P<0.000 1],白种人中共显性基因模型与结直肠癌的发生无关[OR_(白种人)=1.25,95%CI为(0.99,1.58),P=0.06],而黄种人中共显性基因模型与结直肠癌的发生有关[OR_(黄Objective To explore the correlation of adiponectin rs2241766 gene polymorphism and colorectal cancer. Methods Case-control studies about correlation of adiponectin rs2241766 gene polymorphisms and colorectal cancer were searched by computer retrieval on PubMed, Sciencedirect, Embase, the Cochrane Database, OVID Medline, Springer Link, EBSCO Database, CNKI, VIP, Wanfang, and Chinese Biomedicine Database, the retrieval time was from inception of database to September 30, 2017. At the same time, collected similar literatures and references by manual retrieval. Two independent researchers took the mask of study selection and data extraction, Review Manager 5.3 software was used on calculation results with the OR value and 95% confidence interval （95% CI）, on the condition of 5 kinds of gene models. Results A total of 10 case-control studies were included, including 3 460 cases of colorectal cancer and 4 170 controls. Results of meta-analysis showed the effect of 5 kinds of model. ① Allele gene model （G vs T）： in general population and Yellow race, allele gene model was related to occurrence of colorectal cancer [ORtota,= 1.15, 95% CI was （1.07, 1.24）, P=O.O00 1; ORyelloe race=1.16, 95% CI was （1.08, 1.26）, P=0.000 1], but there was no significant difference on relationship between allele gene model and occurrence of colorectal cancer for White IORwhite=1.08, 95% CI was （0.89, 1.30）, P=0.44].② Dominant gene model （TG＋GG vs TT）： in general population and Yellow race, dominant gene model was related to occurrence of colorectal cancer [ORtotal=l.23, 95% CI was （1.12, 1.35）, P〈0.000 1; ORyelloe race =1.24, 95% CI was （1.12, 1.37）, P=〈O.O00 1], but there was no significant difference on relationship between dominant gene model and occurrence of colorectal cancer for White [ORwhite=1.17, 95% CI was （0.93, 1.46）, P=0.17]. ③ Implicit gene model （GG vs TT＋TG）： there was no significant difference on relationship between implicit gene model in 3 kinds of population and

关 键 词：结直肠癌 脂联素 rs2241766位点 基因多态性 META分析 

分 类 号：R735.34[医药卫生—肿瘤]