不同正畸治疗措施对错畸形患者龈沟液MMP-2、TIMP-2水平的影响分析  

Effect of Orthodontic Treatment on Levels of MMP-2 and TIMP-2in Gingival Crevicular Fluids of Malocclusion Patients

作　　者：熊亚芳[1] 朱妮蔓 杨芳[2] XIONG Ya --fang;ZHU Ni -- man;YANG Fang(Department of Stomatology, Ezhou Centre Hospital, E zhou 436000;Department of Stomatolgoy, Ezhou Centre Hospital, E zhou 436000)

机构地区：[1]湖北省鄂州市中心医院口腔科,湖北鄂州436000 [2]湖北省汉川市人民医院口腔科,湖北鄂州436000

出　　处：《口腔医学研究》2018年第5期544-547,共4页Journal of Oral Science Research

摘　　要：目的:分析不同正畸治疗措施对错畸形患者龈沟液基质金属蛋白酶-2(matrix metalloproteinase-2,MMP-2)、金属蛋白酶组织抑制物-2(tissue inhibitors of metalloproteinases-2,TIMP-2)水平的影响。方法:选取医院收治的错畸形患者60例,按照随机数字表法分为A组、B组、C组和D组,每组各15例。所有患者均接受正畸治疗,4组患者分别给予0、50、150g和250g的远中移动初始力。比较4组患者治疗前及治疗1、2、3、4周龈沟液MMP-2、TIMP-2水平及其比值。结果:治疗1、2、3、4周后,B组、C组沟液MMP-2、TIMP-2水平显著高于A组和D组,且C组MMP-2、TIMP-2水平显著高于B组,差异有统计学意义(P<0.05);B组和C组龈沟液MMP-2/TIMP-2比值治疗1周后明显升高,治疗2、3、4周后呈现小幅度降低趋势;A组和D组治疗前后沟液MMP-2、TIMP-2水平比较差异均无统计学意义。结论:龈沟液中MMP-2、TIMP-2水平与正畸力的大小以及持续时间有关,而且龈沟液MMP-2、TIMP-2动态水平变化可作为分析正畸牙加力的重要参考指标。Objective：To analyze the effect of orthodontic treatment on the levels of matrix metalloproteinase-2（MMP-2）and tissue inhibitor of tissue inhibitors of metalloproteinases-2（TIMP-2）in gingival crevicular fluids of patients with malocclusion.Methods：Sixty cases of malocclusion treated in the hospital were selected,which were divided into group A,B,C,and D according to the random number table method（n=15）.All patients were treated with orthodontic treatment,who were given 0,50,150,and 250 g of distal movement initial force,respectively.The level and ratio of MMP-2 and TIMP-2 in gingival crevicular fluids before and 1,2,3 and 4 weeks after treatment were compared.Results：After treatment for 1,2,3,and 4 weeks,the levels of MMP-2 and TIMP-2 in group B and C were significantly higher than those in group A and D.And the levels of MMP-2 and TIMP-2 in group C were significantly higher than those in group B（P〈0.05）.The MMP-2/TIMP-2 ratios of gingival crevicular fluid in group B and C were significantly increased after 1 week,however,little decreased after 2,3,and 4 weeks.There were no significant difference in the levels of MMP-2 and TIMP-2 in group A and D before and after treatment.Conclusion：The levels of MMP-2 and TIMP-2 in gingival crevicular fluid are related to the size and duration of orthodontic force,and the dynamic levels of MMP-2 and TIMP-2 in gingival crevicular fluid can be used as an important reference index to analyze the orthodontic tooth augmentation.

关 键 词：错(牙合)畸形 正畸治疗 基质金属蛋白酶-2 金属蛋白酶组织抑制物-2 

分 类 号：R783.5[医药卫生—口腔医学]