端粒酶调控放射敏感性在恶性肿瘤治疗中的作用进展  

Advances in role of radiation sensitivity regulated by telomerase in cancer therapy

作　　者：赵相轩[1,2] 温锋 卢再鸣[1,2] ZHAO Xiangxuan;WEN Feng;LU Zaiming(Department of Radiology, Shengjing Hospital of China Medical University;Liaoning Provincial Key Laboratory of Medical Imaging, Shenyang 110004, Liaoning Province, China)

机构地区：[1]中国医科大学附属盛京医院放射科 [2]辽宁省医学影像重点实验室,辽宁沈阳110004

出　　处：《肿瘤》2018年第5期498-501,共4页Tumor

基　　金：国家自然科学基金资助项目(编号:31371425;81771947);辽宁省自然科学基金资助项目(编号:2013023056)~~

摘　　要：包括X射线、伽马射线等在内的电离辐射(ionizing radiation,IR)能够诱导肿瘤细胞凋亡,最主要的诱因归结于IR引起的端粒损伤和基因组DNA断裂。尽管IR可以通过诱导肿瘤细胞死亡而治愈部分恶性肿瘤,但是肿瘤细胞对IR的抗性仍严重制约其在肿瘤治疗中的应用。研究表明,端粒酶可以对IR诱导的端粒和染色体损伤进行修复,其在肿瘤细胞对IR的抗性中可能发挥着重要作用,但有关其调控机制尚不明确。本文对近10年来有关端粒酶介导IR敏感性的研究进展进行综述,探讨端粒酶参与调控IR敏感性的分子机制及在肿瘤治疗中的作用,以期为相关研究及肿瘤治疗提供参考资料。Ionizing radiation（IR） including X-ray and γ-ray can induce apoptosis of cancer cells, mainly due to telomere damage and genome DNA breaks caused by IR. Although IR has been used clinically to cure some types of malignant tumors, the inherent or acquired resistance of cancer cells to IR has increasingly been an impediment for its usage. Overwhelming evidence has shown that telomerase is able to repair IR-induced telomere and chromosome damages, which may play key roles in mediating IR resistance. Unfortunately, the underlying mechanisms remain poorly known. This paper reviews the advances in research on telomerase-mediated regulation of IR sensitivity in recent 10 years, in order to clarify the molecular mechanism and the roles of telomerase-mediated regulation of IR sensitivity in cancer therapy and hope to provide useful clues and instructions for IR in cancer therapy.

关 键 词：肿瘤 端粒酶 放射疗法 信号通路 DNA损伤 

分 类 号：R73-36[医药卫生—肿瘤]