溶瘤病毒的抗肿瘤机制及其在临床应用中的研究进展  

Advances in antitumor mechanism of oncolytic virus and its clinical application

作　　者：钱云云 张荣波 吴静 胡东[1] QIAN Yunyun;ZHANG Rongbo;WUJing;HU Dong(Department of Immunology;Department of Biochemistry, Medical School, Anhui University of Science and Technology, Huainan 232001, Anhui Province, China)

机构地区：[1]安徽理工大学医学院免疫学教研室,安徽淮南232001 [2]安徽理工大学医学院生物化学教研室,安徽淮南232001

出　　处：《肿瘤》2018年第5期513-518,共6页Tumor

基　　金：国家自然科学基金(编号:81672445;81571528;81273777);安徽省科技攻关项目(编号:1604a0802091);淮南市科技计划项目基金(编号:2015A2401)~~

摘　　要：溶瘤病毒疗法是指通过溶瘤病毒靶向肿瘤细胞,在细胞内大量复制病毒导致细胞裂解;裂解后释放的病毒分子及相关细胞因子刺激机体产生免疫反应进一步杀伤肿瘤细胞的一种肿瘤治疗手段。溶瘤病毒抗肿瘤的关键在于靶向肿瘤作用和杀伤肿瘤作用。近期,用分子生物技术对野生病毒株进行优化改造的研究旨在使其具有更强的溶瘤效应和更低的不良反应,作为抗肿瘤药物进入临床治疗。本文将就溶瘤病毒的研究发展、作用机制和临床应用等多个方面,对这一新的肿瘤治疗手段作一综述。Oncolytic virus therapy is a new strategy of tumor treatment by special targeting and lysing tumor cells where the virus continuously replicates. The virus molecules and their related cytokines released from these lysed cells induce the anti-tumor immune response to kill tumor cells. The key roles of oncolytic virus rely on the tumor-targeting mechanism and tumor-killing mechanism. Recently, the wild virus strains are optimized by molecular biological technology, and are designed to generate more oncolytic effect and lower side effect as an antitumor drug for clinical treatment. This paper reviews the research development, function mechanism and clinical application of oncolytic virus.

关 键 词：肿瘤 溶瘤病毒疗法 DNA 重组 分子靶向治疗 

分 类 号：R730.58[医药卫生—肿瘤]