PSA与前列腺癌发展和转移相关性的研究进展  

Correlation of prostate-specific antigen with the progression and metastasis of human prostate cancer

作　　者：张树江[1,2,3,4] 孙祖越 ZHANG Shu-jiang;SUN Zu-yue(Department of Pharmacology and Toxicology, Shanghai Institute of Planned Parenthood Research / National Evaluation Center for the Toxicology of Fertility-Regulating Drugs, Shanghai 200032, China;Key Laboratory of Contraceptive Drugs and Devices of National Population and Family Planning Commission of China, Shanghai Insti- tute of Planned Parenthood Research, Shanghai 200032, China;Research Institute of Reproduction and Develop- ment, Fudan University, Shanghai 200032, China;School of Pharmacy, Fudan University, Shanghai 200032, China)

机构地区：[1]上海市计划生育科学研究所药理毒理学研究室/中国生育调节药物毒理检测中心,上海200032 [2]国家人口计生委计划生育药具重点实验室/上海市计划生育科学研究所,上海200032 [3]复旦大学生殖与发育研究院,上海200032 [4]复旦大学药学院,上海200032

出　　处：《中华男科学杂志》2018年第5期457-461,共5页National Journal of Andrology

基　　金：上海实验动物研究基金(17140900801);上海科技服务平台项目(17DZ2293600)~~

摘　　要：前列腺特异性抗原(PSA)是1个前列腺癌诊断和管理生物标志物,并对前列腺癌的发展和/或前列腺原位癌向转移癌的进展有一定作用。本文综述了PSA在人前列腺癌发展中促进前列腺癌发展和转移等的作用,阐述了PSA对前列腺癌发展和转移影响的可能机制,包括丝氨酸蛋白酶活性、以无酶活性形式与细胞膜受体结合发挥作用和抑制免疫功能等,并指出亟待解决的关键问题。Prostate-specific antigen(PSA） is a biomarker for the diagnosis and management of prostate cancer and involved in the development of prostate cancer and/or its progression from the localized to the metastatic stage. This review presents an overview of the roles of PSA in promoting the progression and metastasis of human prostate cancer and its underlying mechanisms,including its serine protease activity,interaction with the cellular membrane receptor,and suppression of specific immune responsiveness,and also points out some of the key problems to be solved.

关 键 词：前列腺特异性抗原 前列腺癌 促进发展 促进转移 丝氨酸蛋白酶活性 细胞膜受体 免疫抑制 

分 类 号：R737.25[医药卫生—肿瘤]