自噬在肝脏缺血再灌注损伤中的作用及研究进展  

Role of autophagy in hepatic ischemia-reperfusion injury

作　　者：李子一[1] 佟立权[1] Zi-Yi Li;Li-Quan Tong(Department of General Surgery, People＇s Hospital of Daqing, Daqing 163316, Heilongjiang Province, China)

机构地区：[1]大庆市人民医院普外科,黑龙江省大庆市163316

出　　处：《世界华人消化杂志》2018年第13期755-759,共5页World Chinese Journal of Digestology

基　　金：黑龙江省自然科学基金资助项目;No.C201310~~

摘　　要：肝脏缺血再灌注损伤是肝脏外科常见的一种并发症,是导致术后肝功能障碍的重要原因.肝脏缺血再灌注损伤的发生机制十分复杂,涉及多种因素.自噬是真核细胞内的一种溶酶体依赖的降解途径,具有维持细胞内环境稳定的作用.自噬在肝脏缺血再灌注损伤的发生发展过程中发挥重要的作用,是目前的研究热点之一,但是其具体作用及机制仍有较大争议.本文就自噬在肝脏缺血再灌注损伤中的作用及其机制作一详尽综述.Hepatic ischemia-reperfusion injury is a common complication of liver surgery and an important cause of liver dysfunction after operation. The pathogenesis of liver ischemia-reperfusion injury is very complex, involving many factors. Autophagy is a lysosomal degradation pathway on which eukaryotic cells rely to maintain the cell homeostasis. Autophagy plays an important role in the process of liver ischemia~ reperfusion injury. However, the specific role and mechanism of autophagy in liver ischemia-reperfusion injury are still controversial. In this paper, we reivew the role and mechanism of autophagy in hepatic ischemia-reperfusion injury.

关 键 词：肝脏缺血再灌注损伤 自噬 线粒体 

分 类 号：R575[医药卫生—消化系统]