水通道蛋白-4与钾离子通道4.1在脊髓水肿中作用机制的研究进展  

Research progress in the role of aquaproin-4 and inward rectifying potassium channel 4.1 in spinal cord edema

作　　者：陈铁戈 党跃修[1] 王明[1] 张东亮 郭永强[1] 张海鸿[1] CHEN Tiege;DANG Yuexiu;WANG Ming;ZHANG Dongliang;GUO Yongqiang;ZHANG Haihong(Department of Orthopedics, Second Hospital, Lanzhou Universit;Orthopedics Key Laboratory of Gansu Province, Lanzhou 730030, Chin)

机构地区：[1]兰州大学第二医院骨科甘肃省骨关节病重点实验室,兰州730030

出　　处：《中南大学学报（医学版）》2018年第5期552-559,共8页Journal of Central South University ：Medical Science

基　　金：甘肃省自然科学基金(1506RJZA245)~~

摘　　要：脊髓水肿是脊髓继发性损伤非常重要的病理生理基础,影响着脊髓损伤的修复与预后。水通道蛋白-4广泛分布于机体各器官,在脑和脊髓中高表达。内向整流钾离子通道4.1是近年发现的表达于中枢神经系统星形胶质细胞上的蛋白,在功能上与水通道蛋白互通。水通道蛋白-4和内向型整流钾离子通道4.1在脊髓水肿形成和消除过程中发挥重要作用,并且对抑制胶质瘢痕形成,促进兴奋性毒物的清除有一定作用。Spinal edema is a very important pathophysiological basis for secondary spinal cord injury, which aff ects the repair and prognosis of spinal cord injury. Aquaporin-4 is widely distributed in various organs of the body, and is highly expressed in the brain and spinal cord. Inward rectifying potassium channel 4.1 is a protein found in astrocytes of central nervous system. It interacts with aquaporins in function. Aquaporin-4 and inward rectifying potassium channel 4.1 play an important role in the formation and elimination of spinal cord edema, inhibition of glial scar formation and promotion of excitotoxic agents exclusion. Th e distribution and function of aquaporin-4 and inward rectifying potassium channel 4.1 in the central nervous system and their expression aft er spinal cord injury have multiple effects on spinal edema. Studies of aquaporin-4 and inward rectifying potassium channel 4.1 in the spinal cord may provide new ideas for the elimination and treatment of spinal edema.

关 键 词：脊髓水肿 水通道蛋白-4 内向型整流钾离子通道4.1 脊髓继发性损伤 中枢神经系统 星形胶质细胞 

分 类 号：R744[医药卫生—神经病学与精神病学]