胰腺癌的免疫治疗及DNT细胞在其治疗中的应用  

Immunotherapy of pancreatic cancer and the application of DNT cell in the therapy of pancreatic cancer

作　　者：邬高华 陈炯 Wu Gaohua;Chen Jiong(Department of General Surgery, the Affiliiated Provincial Hospital of Anhui Medical University, Hefei 230001, China)

机构地区：[1]安徽医科大学附属省立医院普外科,合肥230001

出　　处：《国际外科学杂志》2018年第5期349-352,共4页International Journal of Surgery

基　　金：国家自然科学基金（81071985）;安徽省国际合作项目（1008070038）

摘　　要：胰腺癌是一种恶性度高、预后极差的恶性肿瘤,起病隐匿,易早期转移,进展迅速,尽管临床上不断地提高胰腺癌的切除率,但是术后的生存时间并没有明显延长,且胰腺癌对放疗、化疗均不敏感,因此目前尚无有效的治疗方法.过继免疫治疗是一种治疗恶性肿瘤的重要辅助方法,是指在不损伤患者自身免疫系统的前提下,通过向患者体内注射有效的免疫细胞,杀伤患者体内的恶性肿瘤细胞.近几年发现的DNT细胞,即TCR^＋、CD3^＋、CD4^-、CD8^-T细胞,是具有独特免疫调节功能的T细胞亚群,其表达的Fas/FasL、TNF/TNFR、MHC Ⅰ等,在抗肿瘤、免疫调节、免疫抑制等方面具有重要的作用.Pancreatic cancer is a kind of malignant tumor with a high degree of malignancy and a very poor prognosis.The onset is occult,early metastasis is easy,and progression is rapid.Despite clinically increasing the resection rate of pancreatic cancer,the survival time after surgery is not significantly prolonged.Pancreatic cancer is not sensitive to radiotherapy and chemotherapy,so there is no effective treatment.Adoptive immunotherapy is an important auxiliary method for the treatment of malignant tumors and refers to killing the malignant tumor cells in patients by injecting effective immune cells into the patient without damaging the patient＇s own immune system.The DNT cells discovered in recent years,namely TCR^ ＋,CD3^ ＋,CD4^-,and CD8^-T cells,are T-cell subpopulations with unique immunomodulatory functions,and their expression of Fas/FasL,TNF/TNFR,and MHCI,etc.They have an important role in anti-tumor,immune regulation,immunosuppression,etc.

关 键 词：胰腺肿瘤 免疫调节 免疫治疗 DNT细胞 

分 类 号：R735.9[医药卫生—肿瘤]