实时影像融合虚拟导航联合CEUS引导射频消融治疗肝癌新生或复发病灶  

Real-time virtual navigation system combined with CEUS guided radiofrequency ablation therapy of neonatal or recurrent hepatocellular carcinoma lesions

作　　者：徐倩[1] 林淑芝[1] 董士佳[1] 武金玉[1] 杨薇[2] 吴薇[2] 严昆[2] 陈敏华[2] XU Qian;LIN Shuzhi;DONG Shijia;WU Jinyu;YANG Wei;WU Wei;YAN Kun;CHEN Minhua(Department of Ultrasound, Harbin First Hospital, Harbin 150010, China;Key Laboratory of Carcinogenesis and Translational Research , Department of Ultrasound, Peking University Cancer Hospital ＆ Institute, Beijing 100142, China)

机构地区：[1]哈尔滨市第一医院超声科,黑龙江哈尔滨150010 [2]北京大学肿瘤医院暨北京市肿瘤防治研究所超声科恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《中国医学影像技术》2018年第5期701-704,共4页Chinese Journal of Medical Imaging Technology

基　　金：哈尔滨市自然科学基金(2009RFQQS019)

摘　　要：目的探讨实时影像融合虚拟导航系统(RVS)联合CEUS引导RFA治疗原发性肝细胞癌(HCC)治疗后新生或复发病灶的价值。方法收集111例因HCC接受RFA治疗、且治疗后发现新生或复发病灶患者,对其中78例患者的86个病灶(77个新生病灶和9个复发病灶)行经RVS联合CEUS定位引导RFA治疗(RVS联合CEUS组);对另外33例患者的38个病灶(26个新生病灶和12个复发病灶)行CEUS定位引导RFA治疗(对照组)。计算并比较两组的准确定位率、灭活率和局部复发率。结果 RVS联合CEUS组清晰显示并准确定位病灶84个(84/86,97.67%),对照组25个(25/38,65.79%),差异有统计学意义(P<0.001);RFA治疗后1个月,RVS联合CEUS组的病灶灭活率为95.35%(82/86),高于对照组[76.31%(29/38),P=0.003];RVS联合CEUS组病灶局部复发率为8.14%(7/86),明显低于对照组[36.84%(14/38),χ~2=15.434,P<0.001)。结论 RVS联合CEUS引导可有效提高RFA对于HCC治疗后新生或复发病灶的准确定位率和早期灭活率。Objective To investigate the value of real-time virtual navigation system（RVS）combined with CEUS in guiding radiofrequency ablation（RFA）therapy of neonatal or recurrent lesions of hepatocellular carcinoma（HCC）.Methods Totally 111 patients with neonatal or recurrent lesions of HCC after RFA therapy were enrolled.Seventy-eight patients with 86 lesions（77 neonatal lesions and 9 recurrent lesions）underwent RFA guided by RVS combined with CEUS（RVS combined with CEUS group）,and 33 patients with 38 lesions（26 neonatal lesions and 12 recurrent lesions）underwent RFA guided by CEUS alone（control group）.The precise localization,inactivation rate and local recurrence rate between the two groups were compared.Results Eighty-four lesions（84/86,97.67%）in RVS combined with CEUS group and 25 lesions（25/38,65.79%）in control group were clearly showed and localized（P〈0.001）.One month after RFA therapy,the tumor inactivation rate in RVS combined with CEUS group and control group was 95.35%（82/86）and76.31%（29/38）,respectively（P=0.003）.The local recurrence rate in RVS combined with CEUS group was 8.14%（7/86）,while was 36.84%（14/38）in control group（χ^2=15.434,P〈0.001）.Conclusion RVS combined with CEUS guidance can improve the accurate position rate and early inactivation rate of RFA therapy for neonatal or recurrent lesions of HCC.

关 键 词：射频消融 融合导航系统 超声检查 

分 类 号：R735.7[医药卫生—肿瘤] R445.1[医药卫生—临床医学]