乙肝肝硬化患者抑郁焦虑与Child-Pugh肝功能分级的关系  

Relationship Between Depression and Anxiety and Child-Pugh Liver Function Classification in Patients with Hepatitis B Cirrhosis

作　　者：康继厚 陈克河 曾静 胡林莉 KANG Jihou;CHEN Kehe;ZENG Jing;et al(Xinyang Central Hospital, Xinyang 464000, Chin)

机构地区：[1]河南省信阳市中心医院

出　　处：《中国健康心理学杂志》2018年第5期699-702,共4页China Journal of Health Psychology

摘　　要：目的：探讨乙肝肝硬化患者抑郁焦虑与Child-Pugh肝功能分级的关系。方法：将83例乙肝肝硬化患者作为肝硬化组,选取同期年龄性别匹配的体检健康者50例作为对照组,采用抑郁自评量表（SDS）、焦虑自评量表（SAS）评测两组患者抑郁、焦虑状况,并分析抑郁、焦虑评分分值与Child-Pugh肝功能分级的相关性。结果：乙肝肝硬化组SDS评分、SAS评分分值明显高于对照组,差异有统计学意义（t=15.602,13.018;P〈0.001）;乙肝肝硬化组抑郁、焦虑发生率分别为38.55%、28.92%,明显高于对照组的18.0%、12.0%,差异有统计学意义（χ^2=6.182,5.111;P〈0.05）。Child-Pugh A级患者SDS评分、SAS评分分值明显低于Child-Pugh B级患者和Child-Pugh C级患者,且Child-Pugh B级和Child-Pugh C级患者比较差异有统计学意义（F=7.261,5.310;P〈0.01）;Child-Pugh A级抑郁、焦虑发生率分别为18.75%、12.50%低于Child-Pugh C级的52.63%、42.11%（χ^2=7.511,4.441;P〈0.05）,但Child-Pugh A级和B级、Child-Pugh B级和C级组间比较差异无统计学意义（χ^2=0.796,0.473,3.125,3.420;P〉0.05）。结论：乙肝肝硬化患者Child-Pugh肝功能分级与抑郁、焦虑评分分值存在正相关关系。Objective：To investigate the relationship between depression and anxiety and Child-Pugh liver function classification in patients with hepatitis B cirrhosis.Methods：A total of 83 patients with hepatitis B cirrhosis were selected as the liver cirrhosis group,and 50 matched healthy subjects were selected as the control group.The status of depression and anxiety in the two groups was evaluated by the self-rating Depression Scale（SDS）and the self-rating Anxiety Scale（SAS）,and the correlation of scores of depression and anxiety with Child-Pugh liver function classification was analyzed.Results：Scores of SDS and SAS in the hepatitis B cirrhosis group were significantly higher than those in the control group（t=15.602,13.018;P〈0.001）.The incidence of depression and anxiety in the hepatitis B cirrhosis group were higher than those in the control group（38.55% and 28.92% vs 18.0% and 12.0%）（χ^2=6.182,5.111;P〈0.05）.SDS and SAS scores of Child-Pugh grade A patients were significantly lower than those of Child-Pugh grade B patients and Child-Pugh grade C patients,and there were statistically significant differences between Child-Pugh grade B patients and Child-Pugh grade C patients（F=7.261,5.310;P〈0.01）.The incidence rates of depression and anxiety in Child-Pugh grade A patients were lower than those in Child-Pugh grade C patients（18.75%,12.50% vs 52.63%,42.11%）（χ^2=7.511,4.441,P〈0.05）,but there was no significant difference between Child-Pugh grade A and grade B,between Child-Pugh grade B and grade C（χ^2=0.796,0.473,3.125,3.420;P〉0.05）.Conclusion：There is a positive correlation between the Child-Pugh grade of liver function and the scores of depression and anxiety in patients with hepatitis B cirrhosis.

关 键 词：抑郁 焦虑 肝功能 乙肝肝硬化 

分 类 号：R749.92[医药卫生—神经病学与精神病学]