肝动脉栓塞化疗术后甲胎蛋白变化与疗效的相关性分析  

Correlation analysis of alpha fetoprotein changes and therapeutic effect after transcatheter arterial chemoembolization

作　　者：崔怀中 王妙婵 徐爱芳 祁克信 CUI Huai-zhong;WANG Miao-chan;XU Ai-fang;QI Ke-xin(Clinical Laboratory, Xixi Hospital of Hangzhou（ the Sixth People＇s Hospital of Hangzhou） , Hangzhou, Zhejiang 310023, China)

机构地区：[1]杭州市西溪医院(杭州市第六人民医院)检验科,浙江杭州310023 [2]杭州市西溪医院(杭州市第六人民医院)放射科,浙江杭州310023

出　　处：《中国卫生检验杂志》2018年第10期1220-1222,共3页Chinese Journal of Health Laboratory Technology

基　　金：杭州市科技发展计划重点专病专科项目(20160533-B55)

摘　　要：目的探讨原发性肝癌患者肝动脉栓塞化疗术(TACE)后甲胎蛋白(AFP)的变化与治疗效果的关系。方法回顾性纳入2014年1月-2017年6月在本院行TACE治疗并具有完整随访资料的原发性肝癌(PLC)患者104例,收集其术前及术后2周的AFP测定数据,根据其术后1个月CT或MRI结果将患者分为未见活性灶组和可见活性灶组,通过统计学分析2组患者术前AFP、术后两周AFP、AFP术后2周下降百分比之间的差异以及与疗效的相关性。结果 2组患者间术前AFP、术后2周AFP差异无统计学意义(P>0.05);2组患者间术后2周AFP下降百分比差异有统计学意义(P<0.01)。通过受试者工作特征曲线(ROC)分析,采用术后2周AFP下降百分比预测是否存在活性灶有统计学意义(P<0.01),曲线下面积为0.848。结论 AFP术后2周下降百分比与治疗效果相关,可用于预测TACE治疗效果。Objective To investigate the relationship between the changes of alpha fetoprotein（ AFP） and therapeutic efficacy after transcatheter arterial chemoembolization（ TACE） in patients with hepatocellular carcinoma（ HCC）. Methods We retrospectively included 104 patients with primary hepatocellular carcinoma（ PLC） who underwent TACE treatment in our hospital from January 2014 to June 2017 and had complete follow-up data. Two weeks＇ AFP measurement data was collected preoperatively and postoperatively. According to the CT or MRI results 1 month after surgery,the patients were divided into no active focus group and visible active focus group. The differences on preoperative AFP,AFP after two weeks of surgery,and the decline percentage of AFP after 2 weeks of surgery were analyzed between the two groups,and their correlation with the efficacy was also analyzed. Results There was no statistical significance on the difference between the two groups in preoperative AFP and 2 weeks after operation（ P〉0. 05）. There was statistical significance on the difference in the decline percentage of AFP between the two groups at 2 weeks postoperatively（ P〈0. 01）. According to ROC analysis,it was statistically significant to predict the percentage of AFP decline at 2 weeks after surgery,and the area under the curve was 0. 848. Conclusion The percentage decrease in the 2 weeks after AFP is related to the therapeutic effect and can be used to predict the effect of the treatment.

关 键 词：原发性肝癌 肝动脉栓塞化疗术 甲胎蛋白 

分 类 号：R735.7[医药卫生—肿瘤]