FOXL2的研究现状及其调控机制  

Current Research and the Regulation Mechanism of FOXL2

作　　者：吴军[1] 王迪 苗春雷[1] 韩阳阳 Wu Jun;Wang Di;Miao Chunlei;Han Yangyang(Plastic Surgery Institute, Weifang Medical University, Weifang 261042, China;College of Biological Science and Technology, Weifang Medical University, Weifang 261053, China)

机构地区：[1]潍坊医学院整形外科研究所,潍坊261042 [2]潍坊医学院生物科学与技术学院,潍坊261053

出　　处：《中国细胞生物学学报》2018年第4期602-607,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81501683);山东省自然科学基金(批准号:ZR2015HL057;ZR2016HB72);潍坊医学院教师公派教师国内访学项目资助的课题~~

摘　　要：FOXL2(winged helix/forkhead transcription factor gene 2)基因是定位于3q22.3区域的单一外显子基因,属于叉头框(forkhead box,FOX)转录因子家族成员之一,与小睑裂综合征、卵巢早衰(premature ovarian failure,POF)以及不孕不育相关并参与性别决定。迄今为止,围绕FOXL2展开的研究仍然是相关领域的一大热点。该文综述了FOXL2在相关领域的研究进展:FOXL2基因突变与BPES(blepharophmiosis-ptosis-epicanthus inversus syndrome)在基因型–表型上的对应关系;FOXL2以何种方式参与了哪些生命进程及其时空表达;作为一个转录因子FOXL2调控的下游靶基因及其功能。该综述将为深入研究FOXL2基因功能及作用机制提供理论依据。Winged helix/forkhead transcription factor gene 2（FOXL2）, as a single exon gene, located in 3 q22.3 area, which belongs to the large family of forkhead/winged-helix transcription factors, is associated with the blepharophmiosis-ptosis-epicanthus inversus syndrome（BPES）, premature ovarian failure（POF）, and sex determination. Till now, the studies on FOXL2 are still hot issues in related fields. In this review, we summarized the recent research processes of FOXL2, including the genotype-phenotype corresponding relationship between FOXL2 gene mutation and BPES; the roles of FOXL2 in the physiological process of life, and the spatio-temporal expression of FOXL2; besides, we also reviewed the downstream genes and their functions of FOXL2 as a transcription factor. This review aims at helping researchers to understand the function and mechanism of FOXL2 deeply and providing the related theoretical support in this field.

关 键 词：FOXL2 BPES 卵巢早衰 调控 

分 类 号：R363[医药卫生—病理学]