大剂量盐酸氨溴索对NSCLC围术期患者血清炎性因子、氧自由基表达水平和肺功能的影响  

Effects of high-dose ambroxol hydrochloride on serum inflammatory cytokines,oxygen free radicals and pulmonary function in patients with NSCLC during perioperative period

作　　者：齐凯[1] 熊汉鹏[1] 刘小雄[1] 谢琰[1] 熊国江[1] 吕伟[1] 邓海龙[1] QI Kai;XIONG Han-peng;LIU Xiao-xiong;XIE Yan;XIONG Guo-jiang;Lü Wei;DENG Hai-long(Surgical 3 Department of Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330006, Chin)

机构地区：[1]江西中医药大学附属医院外三科,江西南昌330006

出　　处：《热带医学杂志》2018年第5期650-653,657,共5页Journal of Tropical Medicine

基　　金：江西省科技计划项目(20135BBG70003)

摘　　要：目的探讨大剂量盐酸氨溴索对非小细胞肺癌(NSCLC)围术期患者血清炎性因子、氧自由基和肺功能的影响。方法收集2013年12月至2016年6月于本院行开胸行肺叶切除术治疗的NSCLC患者86例,随机分为对照组(n=42)和观察组(n=44),对照组于术前7 d至术后7 d采用常规剂量盐酸氨溴索(每日30 mg)治疗,观察组则采用大剂量盐酸氨溴索(每日300 mg)治疗。比较两组患者治疗前后肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)等炎症指标,丙二醛(MDA)、超氧化物歧化酶(SOD)等氧化指标改善情况,比较两组患者肺功能指标改善情况及不良反应情况。结果两组患者治疗前炎症因子、氧化应激指标、肺功能等比较差异无统计学意义(P>0.05)。治疗后,两组患者TNF-α、IL-6、MDA等指标升高,SOD则降低,但观察组TNF-α、IL-6、MDA数值低于对照组,SOD高于对照组,差异统计学意义(P<0.05);治疗后患者第1秒用力呼气量(FEV1)、用力肺活量(FEV)、FEV1/FVC等肺功能指标降低,但观察组数值仍高于对照组(P<0.05);对照组不良反应发生率为9.52%(4/42),观察组为11.90%(5/42),两组比较差异无统计学意义(P>0.05)。结论对NSCLC患者围术期应用大剂量盐酸氨溴索,可有效减轻炎症及氧化应激反应,改善肺功能,优于常规剂量治疗,值得推广。Objective To investigate the effect of high dose of ambroxol hydrochloride on serum inflammatory factors,oxygen free radicals and pulmonary function in patients with non-small cell lung cancer（NSCLC）during perioperative period. Methods From December 2013 to June 2016,86 patients with non-small cell lung cancer who underwent lobectomy were randomly divided into two groups：observation group（n=44）and control group（n=42）. Control group was treated with routine dose of ambroxol hydrochloride;observation group was treated with high-dose ambroxol hydrochloride.Tumor necrosis factor-α（TNF-α）and interleukin-6（IL-6）levels were compared between the two groups before and after treatment,and the malondialdehyde（MDA）and superoxide dismutase（SOD）levels and improvement of lung function of two groups were compared. Results There was no significant difference in inflammatory factors,oxidative stress indexes,and lung function between the two groups before treatment（P〈0.05）. After treatment,TNF-α,IL-6,MDA and other indicators increased in both groups,SOD decreased,but the TNF-α,IL-6,and MDA levels in the observation group were lower than those in the control group,and the SOD was higher;the differences were significant（P〈0.05）. After the treatment,the patient＇s first-second forced expiratory volume（FEV1）,forced vital capacity（FEV）,FEV1/FVC and other pulmonary function indicators decreased,but the observation group values were still higher than those of the control group （P〈0.05）. The incidence of adverse reactions was 9.52%（4/42）in the control group and 11.90%（5/42）in the observation group;there was no significant difference between the two groups（P〈0.05）. Conclusion The use of high-dose ambroxol hydrochloride in the perioperative period of non-small cell lung cancer patients could effectively reduce inflammation and oxidative stress,improve lung function,better than conventional dose therapy,and it is worth promoting.

关 键 词：大剂量盐酸氨溴索 非小细胞肺癌 围术期 炎性因子 氧自由基 肺功能 

分 类 号：R734.2[医药卫生—肿瘤]